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S 3304

目录号: PL07407 纯度: ≥99%

S 3304 是一个新型的基质金属蛋白酶 (MMP) 抑制剂, 且对 MMP-2 和 MMP-9 有特异的抑制活性。

CAS No. :203640-27-1

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中文名称	S 3304
中文别名	(2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
英文名称	S 3304
英文别名	(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid;S 3304;BK459F050X;D-Tryptophan, N-((5-((4-methylphenyl)ethynyl)-2-thienyl)sulfonyl)-;D-Tryptophan, N-((5-(2-(4-methylphenyl)ethynyl)-2-thienyl)sulfonyl)-;(R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid;D-Tryptophan, N-[[5-[(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-;D-Tryptophan, N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfony
Cas No.	203640-27-1
分子式	C₂₄H₂₀N₂O₄S₂
分子量	464.56
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

S 3304 是一个新型的基质金属蛋白酶 (MMP) 抑制剂, 且对 MMP-2 和 MMP-9 有特异的抑制活性。

生物活性

S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

性状

Solid

IC50 & Target[1][2]

MMP-9

体外研究(In Vitro)

S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Chiappori AA, et al. A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inhibitor, in patients with advanced and refractory solid tumors. Clin Cancer Res. 2007 Apr 1;13(7):2091-9.

溶解度数据	In Vitro: DMSO : ≥ 83.3 mg/mL (179.31 mM)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

S 3304

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