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Diethyl-pythiDC

目录号: PL07413 纯度: ≥99%

Diethyl-pythiDC 是胶原蛋白脯氨酰4-羟化酶 (CP4Hs) 抑制剂。

CAS No. :1821370-70-0

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中文名称	Diethyl-pythiDC
英文名称	Diethyl-pythiDC
英文别名	Diethyl-pythiDC;6-(5-Ethoxycarbonyl-thiazol-2-yl)-nicotinic acid ethyl ester;C(C)OC(=O)C1=CN=C(S1)C1=NC=C(C=C1)C(=O)OCC;ethyl 2-(5-ethoxycarbonylpyridin-2-yl)-1,3-thiazole-5-carboxylate
Cas No.	1821370-70-0
分子式	C₁₄H₁₄N₂O₄S
分子量	306.34
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Diethyl-pythiDC 是胶原蛋白脯氨酰4-羟化酶 (CP4Hs) 抑制剂。
生物活性	Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).
性状	Solid
IC50 & Target[1][2]	CP4H
体外研究(In Vitro)	Diethyl-pythiDC inhibits CP4H activity in cultured cells at concentrations that do not cause iron deficiency. MDA-MB-231 cells are treated with biheteroaryl dicarboxylates, and assayed for cytotoxicity and indicators of iron deficiency. None of the esterified biheteroaryl dicarboxylates exhibited cytotoxic activity at high micromolar concentrations. Cells treated with dihydroxybenzoate (EDHB demonstrate a strong iron-deficient phenotype. In contrast, cells treated with Diethyl-pythiDC (Diethyl pythiDC) appear to be normal at concentrations as high as 500 μM. Treatment with Diethyl-pythiDC and low levels of diethyl pyimDC does not affect the level of TfR, HIF-1α, or ferritin. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Vasta JD, et al. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells. ACS Chem Biol. 2016 Jan 15;11(1):193-9.

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (108.80 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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