D-64131|74588-78-6|-陌孚医药/Medlife

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D-64131

目录号: PL07213 纯度: ≥98%

CAS No. :74588-78-6

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中文名称	D-64131
中文别名	(5-甲氧基-1H-吲哚-2-基)苯基甲酮;D-64131
英文名称	D-64131
英文别名	Methanone,(5-methoxy-1H-indol-2-yl)phenyl-;(5-methoxy-1H-indol-2-yl)-phenylmethanone;D 64131;D-6413;D-64131;5-methoxy-1H-2-indolylphenyl-1-methanone;5-methoxy-2-benzoylindole;Tocris-1643;(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE;(5-Methoxy-1H-indol-2-yl)(phenyl)methanone;(5-Methoxy-1H-indol-2-yl)-phenyl-methanone;2-Benzoyl-5-methoxyindole;ICMIJSRDISNKOC-UHFFFAOYSA-N;HMS3676P03;HMS3268K07;BCP06496;BS0058;BDBM50107658;3570AH;API0002200
Cas No.	74588-78-6
分子式	C₁₆H₁₃NO₂
分子量	251.28
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	D-64131 是一种具有口服活性的微管蛋白 (tubulin) 抑制剂，抑制微管蛋白聚合的 IC₅₀ 值为 0.53 μM。D-64131 具有抗丝分裂活性。D-64131 可用于癌症研究。
生物活性	D-64131 is an orally active tubulin inhibitor, with an IC 50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research.
性状	Solid
IC50 & Target[1][2]	IC50: 0.53 μM (tubulin polymerization)
体外研究(In Vitro)	D-64131 is antimitotic by binding to β-tubulin, thereby destabilizing microtubules and arresting mitotic cells in the M-phase. D-64131 inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM. D-64131 is cytotoxic toward MDR/MRP tumor cell lines. D-64131 suppresses U373 proliferation and cell cycle with IC50s of 74 nM and 62.7nM, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model. D-64131 has oral bioavailability and is well tolerated at efficacious doses. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Thomas Beckers, et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119. [2]. S Mahboobi, et al. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J Med Chem. 2001 Dec 20;44(26):4535-53.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (397.96 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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