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Rosabulin

目录号: PL07195 纯度: ≥98%

Rosabulin (STA 5312) 是一种有效的具有口服活性的微管 (microtubule) 抑制剂，可抑制微管组装。Rosabulin 具有广谱抗肿瘤活性。

CAS No. :501948-05-6

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中文名称	Rosabulin
中文别名	罗沙布林;3-[(4-氰基苯基)甲基]-N-(3-甲基-5-异噻唑基)-alpha-氧代-1-中氮茚乙酰胺
英文名称	Rosabulin
英文别名	Rosabulin;3-[(4-Cyanophenyl)methyl]-N-(3-methyl-5-isothiazolyl)-alpha-oxo-1-indolizineacetamide;2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide;STA 5312;I01-9450;STA-5312;UNII-6Z674O12T6
Cas No.	501948-05-6
分子式	C₂₂H₁₆N₄O₂S
分子量	400.45
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Rosabulin (STA 5312) 是一种有效的具有口服活性的微管 (microtubule) 抑制剂，可抑制微管组装。Rosabulin 具有广谱抗肿瘤活性。

产品详情

Rosabulin (STA 5312) 是一种有效的具有口服活性的微管 (microtubule) 抑制剂，可抑制微管组装。Rosabulin 具有广谱抗肿瘤活性。

生物活性

Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity.

性状

Solid

体外研究(In Vitro)

Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC50 values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Keizo Koya,et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Cancer Res, Volume 45, 2004.

溶解度数据	In Vitro: DMSO : 50 mg/mL (124.86 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

[1]. Keizo Koya,et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Cancer Res, Volume 45, 2004.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Rosabulin

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