Avanbulin (BAL27862) 是一种有效的秋水仙碱位点结合的微管蛋白 (tubulin) 装配抑制剂。Avanbulin 在 37 °C 抑制微管蛋白组装 (IC₅₀=1.4 μM)。Avanbulin 与微管蛋白结合的 K_d 值为 244 nM。Avanbulin 可用于癌症和细胞分裂的研究。

Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC 50 of 1.4 μM. Avanbulin binds to tubulin with an apparent K d value of 244 nM. Avanbulin can be used for the research of cancer and cell division.

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Avanbulin (0-4 μM) binds to tubulin in the site as Colchicine with an apparent Kd value of 244 nM..
Avanbulin (50 μM; 0, 10, 20, 30, 60 min) induces the proteolysis of tubulin.
Avanbulin (33 nM; 0, 10, 20, 30, 60 min; HeLa-tubGFP cells) collapses the mitotic spindle and forms the tiny tubulin aggregates.
Avanbulin does not induce the formation of tubulin oligomers.
Avanbulin induces growth inhibition of 23 tumor cell lines with a median relative IC50 of 13.8 nM (96 hours) .Avanbulin (6 nM and 20 nM) inhibits the migration of GBM6 and GBM9 cells.
Avanbulin (6 nM and 20 nM; GBM6-shEB1 and GBM6-sh0 cells) triggers astrocytic differentiation of GBM6 in an EB1-dependent manner.
Avanbulin (12? nM; 4? h) reduces kinetochore-microtubule (KT–MT) occupancy of MG132(10 μM; 2h) treated hTert-RPE1 eGFP-α-tubulin cells.
Avanbulin (12 ?nM; 4

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Prota AE, et al. The novel microtubule-destabilizing drug avanbulin binds to the colchicine site of tubulin with distinct effects on microtubule organization. J Mol Biol. 2014 Apr 17;426(8):1848-60.
[2]. Kolb EA, et al. Initial testing (stage 1) of BAL101553, a novel tubulin binding agent, by the pediatric preclinical testing program. Pediatr Blood Cancer. 2015 Jun;62(6):1106-9.

In Vitro: DMSO : 250 mg/mL (645.34 mM; Need ultrasonic)配制储备液