GLPG2938|2130996-00-6|-陌孚医药/Medlife

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GLPG2938

目录号: PL06764 纯度: ≥98%

CAS No. :2130996-00-6

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中文名称	GLPG2938
英文名称	GLPG2938
英文别名	GLPG2938;C(C)OC1=NC(=CC(=C1)NC(=O)NCC=1N=NC(=C(C=1)C)C=1C(=NN(C=1)C)C(F)(F)F)C(F)(F)F;1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea
Cas No.	2130996-00-6
分子式	C₂₀H₁₉F₆N₇O₂
分子量	503.40
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	GLPG2938 是一种有效和选择性 S1P2 拮抗剂。GLPG2938 可用于特发性肺纤维化的研究。
生物活性	GLPG2938 is a potent and selective S1P2 antagonist. GLPG2938 can be used for the research of idiopathic pulmonary fibrosis.
性状	Solid
IC50 & Target[1][2]	S1PR2
体外研究(In Vitro)	GLPG2938 (0.5~5 μM; HPF cells) significantly prevents the S1P-mediated contraction at all tested concentrations. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	GLPG2938 (1~10 mg/kg; p.o.) displays a marked protective effect at all dosed tested, resulting in statistically significant reduction of the Ashcroft score. GLPG2938 shows good pharmacokinetics, with long half-life, low clearance, and good bioavailability in all species, especially in dogs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Mammoliti O, et al. Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmona

溶解度数据	In Vitro: DMSO : 100 mg/mL (198.65 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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