Radioprotectin-1 是一种高效特异性的溶血磷脂酸受体 2 (LPA₂) 激动剂，EC₅₀ 值为 25 nM (鼠源 LPA₂ 亚型) 。

Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA 2 ), with an EC 50 value of 25 nM for murine LPA 2 subtype.

Solid

EC50: 25 nM (murine LPA2 subtype)

Radioprotectin-1 is a potent agonist of LPA2 with an EC50 of 5 pM and functions as a full agonist at the human ortholog of LPA2.
Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA2 either endogenously or after transfection.
has not independently confirmed the accuracy of these methods. They are for reference only.

Radioprotectin-1 is a high-potency specific agonist of the murine LPA 2 GPCR .
Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) .
Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA 2 GPCR in Lgr5stem cells.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Kuo B, et al. The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids. Cell Signal. 2018 Nov;51:23-33.

In Vitro: DMSO : 125 mg/mL (256.72 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (insoluble)配制储备液