Poloxamer 407|9003-11-6|(泊洛沙姆 407 (F127); PEG-PPG-PEG, 12600 (Average Mn))-陌孚医药/Medlife

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Poloxamer 407 (Synonyms: 泊洛沙姆 407 (F127); PEG-PPG-PEG, 12600 (Average Mn))

目录号: PL06782

CAS No. :9003-11-6

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PL06782-1g	1g	询价	询价
PL06782-5g	5g	询价	询价

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中文名称	Poloxamer 407
中文别名	聚醚多元醇;聚醚;泊洛沙姆;环氧丙烷与环氧乙烷的聚合物;聚氧丙烯聚氧乙烯共聚物;泊洛沙姆124;泊洛沙姆181;泊洛沙姆182;泊洛沙姆184;聚醚 F127;聚醚F188;聚醚L65;聚醚 P123;丙二醇嵌段聚醚;丙二醇嵌段聚醚 pluronic F38 泊洛沙姆 poloxamer;丙二醇嵌段聚醚 pluronic F68 泊洛沙姆 poloxamer;丙二醇嵌段聚醚 pluronic L44 泊洛沙姆 poloxamer;丙二醇嵌段聚醚 pluronic L45 泊洛沙姆 poloxamer;丙二醇嵌段聚醚 pluronic L61 泊洛沙姆 poloxamer;丙二醇嵌段聚醚 pluronic L62 泊洛沙姆 poloxamer;丙二醇嵌段聚醚 pluronic L64 泊洛沙姆 poloxamer;丙二醇嵌段聚醚 pluronic P65 泊洛沙姆 poloxamer;泊洛沙姆 Pluronic 丙二醇嵌段聚醚;泊洛沙姆丙二醇嵌段聚醚 poloxamer L35;泊洛沙姆（泊洛萨姆）;泊洛沙姆,聚醚3050,330N;泊洛沙姆188;泊洛沙姆338;泊洛沙姆407;泊洛扎林;聚(乙二醇)-block-聚(丙二醇)-block-聚(乙二醇);聚醚 F68;聚醚(Polyethylene-polypropylene glycol);聚醚（泊洛沙姆）;聚醚,Polyethylene-polypropylene glycol;聚醚3010;聚醚多元醇二羟基聚醚N210(1000D);聚醚多元醇(PPG);聚醚多元醇原药;聚氧丙烯氧化乙烯甘油醚;聚氧乙烯聚氧丙烯酚醛树酯(160E.O.) (30P.O.);聚氧乙烯聚氧丙烯醚;嵌段聚醚F123;嵌段聚醚F127;嵌段聚醚F68;嵌段式聚醚F-127;嵌段式聚醚F-68;盐酸氨溴素泊洛沙姆;4 共聚物;6 共聚物;PO 嵌段共聚物;泊洛尼克;泊洛沙姆124泊洛沙姆181泊洛沙姆182泊洛沙姆184;泊洛沙姆F127;泊洛沙姆F68;改性聚醚;环氧丙烷与环氧乙烷的共聚物;聚醚多元醇,泊洛沙姆;聚氧丙烯聚氧乙烯嵌段落共聚物;聚(丙二醇)-block-聚(乙二醇)-block-聚(丙二醇);聚(乙二醇)-嵌-聚(丙二醇)-嵌-聚(乙二醇);聚丙二醇-聚乙二醇-聚丙二醇三嵌段共聚物;聚氧乙烯聚氧丙烯;高纯度，泊洛沙姆188，可小包装零售;丙二醇嵌段聚醚L-44;泊洛沙姆 188；407;泊洛沙姆407 F127;泊洛沙姆 407
英文名称	Poloxamer 407
英文别名	Poloxalene;BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL;SYNPERONIC F 108;SYNPERONIC L 121;SYNPERONIC L 122;SYNPERONIC P 105;SYNPERONIC P 85;PEG-PPG-PEG, Pluronic P-123;PLURONIC, F-117 PHARMACEUTICAL GRADE USP NF;Poloxamer Solid;Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol);Polyethylene-polypropylene glycol;Polyether polyol;average Mn ~13,000;average Mn ~5,800;average Mn 3600-3700;average Mn 8000-10000;average mol wt 8350;F68;L61;PEG;PEG-PPG-PEG [average MW (5800)];POE condensate;Poloxamer;Poloxanlene;POP;PPG-17;PPG-18;SYNPERONIC PE(R);synperonic CAS;PEG-PPG-PEG;Pluronic® P-123;Pluronic® L-31;Pluronic® L31;Pluronic® L-35;Pluronic® L-61;Pluronic® L-81;Pluronic® L-64;Pluronic® L-121;Pluronic® F-68;Pluronic® F-108;Lutrol® F68;Poloxamer 188;Lutrol® F 127;Poloxamer 407;Lμtrol® micro 127;Poloxamer 407, micronized;PPG-PEG-PPG;Pluronic® 17R4;Lμtrol® micro 68;Poloxamer 188, micronized;Pluronic® 31R1;Pluronic® 10R5;Polosham 188;泊洛沙姆188;synperonicpeR/F68;kolliphor P188;P407;Pluronic F-127;pluronic block copolymer p85;Therabloat (TN);ExpertGel 56;Poloxamer 403;Poloxamer 401;Poloxamer 338;Poloxamer 217;Poloxamer 183;Poloxamer 335;Poloxamer 333;Poloxamer 184;Poloxamer 181;Poloxamer 334;Poloxamer 237;Poloxamer 234;Poloxamer 182;Poloxamer 185;Poloxamer 124;Acclaim 2220N;Blaunon P 124;PLU8QA2TOV;JX0HIX6OAG;Poloxalene (USP/INN);Adeka Pluronic L 101;Poloxalene [USAN:INN];TUF2IVW3M2;LQA7B6G8JG;UNI;Pluronic P-85;Poloxamer188;Kolliphor P407;Kolliphor P188;Celastrol;Poloxamer 188
Cas No.	9003-11-6
分子式	C₇H₁₆O₄
分子量	164.20
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Poloxamer 407 是一种非离子型表面活性剂，Poloxamer 407 具有 100% 的活性并且对细胞相对无毒性的，常与染料 AM 酯一起使用，以增强其水溶性。Poloxamer 407 也是一种 lipoprotein lipase 抑制剂。
生物活性	Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8? AM and Quest Rhod-4? AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor.
性状	Solid
体外研究(In Vitro)	Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Dissolve 1 g of Poloxamer 407 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Poloxamer 407 in 10 mL DMSO to make a 20% (w/v) stock solution. These may require heating from 40 to 50°C for about 30 minutes. Store solution at room temperature. Do not refrigerate or freeze the Poloxamer 407 solution since it may precipitate. If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use. 2. Dilute the 10% or 20% Poloxamer 407 stock solution into the cell-loading buffer such as Hanks and 20 mM Hepes buffer (HHBS) at 1:1000 to 1:500 dilution to achieve a 0.02 to 0.04% working solution.
体内研究(In Vivo)	Poloxamer 407 (0.25 g/kg; i.p.; every other day for 7 weeks) induces hypertriglyceridemia but decreases atherosclerosis in Ldlr mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: L
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Antunes FE, et al. Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation. Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):42-8. [2]. Peng X, et al. Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr-/- Mice. Cells. 2022 May 30;11(11):1795.

溶解度数据	In Vitro: H₂O : 110 mg/mL (Need ultrasonic)In Vivo:

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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