OTUB1/USP8-IN-1 是一种有效的双重 OTUB1/USP8 抑制剂，抑制 OTUB1 和 USP8 的 IC₅₀ 值分别为 0.17 和 0.28 nM。OTUB1/USP8-IN-1 可用于癌症的研究。

OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC 50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer.

Solid

IC50: 0.17 nM (OTUB1) and 0.28 nM (USP8)

OTUB1/USP8-IN-1 (compound 61; 10 nM-10 μM; 72 h) has antiproliferative effects in KRAS-WT (H1975, EBC-1, H1703) and KRAS-mutated (H23, A549) NSCLC cell lines.
OTUB1/USP8-IN-1 (500 nM; 24 h) decreases in protein levels of both UBE2N and EGFR in H1975 cells.
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay OTUB1/USP8-IN-1 (compound 61; 10 nM-10 μM; 72 h) decreases the tumor burden in the H1975 xenograft mouse model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c nude mice

运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tan L, et, al. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11.