XL177A 是一种高效选择性的不可逆 USP7 抑制剂，IC₅₀ 为 0.34 nM。XL177A 通过 p53 依赖性机制引发癌杀伤细胞作用。

XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC 50 of 0.34?nM. XL177A elicits cancer cell killing through a p53-dependent mechanism.

Solid

XL177A is a potent USP7 inhibitor and p53 stabilizer in cyto. XL177A suppresses cancer cell growth predominantly through a p53-dependent mechanism. XL177A labels the catalytic cysteine, C223, of USP7 with exquisite selectivity for USP7 across the DUBome and human proteome.
XL177A (1 μM) induces complete G1 arrest in MCF7 cells after 24?hours.
Treatment of MCF7 cells, which express WT TP53, with XL177A (0.001- 10 μM) induces rapid degradation of HDM2 within 2?hours, followed by increases in p53 and downstream p21 protein levels.
has not independently confirmed the accuracy of these methods. They are for reference only.

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Powder -20°C 3 years；4°C 2 years

[1]. Nathan J Schauer, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep.2020 Mar 24;10(1):5324.

In Vitro: DMSO : 25 mg/mL (29.02 mM; Need ultrasonic)配制储备液