RA-9|919091-63-7|-陌孚医药/Medlife

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RA-9

目录号: PL03607 纯度: ≥98%

CAS No. :919091-63-7

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中文名称	RA-9
中文别名	(3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮;化合物RA-9
英文名称	RA-9
英文别名	4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,3E)-;(3E,5E)-3,5-Bis[(4-Nitrophenyl)methylene]-4-piperidinone;4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,5E)-;RA-9 UPS inhibitor;RA-9;(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-4-piperidinone (ACI)
Cas No.	919091-63-7
分子式	C₁₉H₁₅N₃O₅
分子量	365.34
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	RA-9 是一种高效选择性蛋白酶体相关 DUBs 抑制剂，具有良好的毒性和抗癌活性。RA-9 阻断泛素依赖性蛋白降解而不影响 20S 蛋白酶体蛋白水解活性。RA-9 选择性诱导卵巢癌细胞株和供体原代培养细胞凋亡。RA-9 诱导卵巢癌细胞内质网应激反应。
生物活性	RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells.
性状	Solid
体外研究(In Vitro)	RA-9 (10-30 μM; 48 hours) inhibits growth of ovarian cancer cell lines and primary cultures. RA-9 (1.25-5 μM; 18 hours) causes cell cycle arrest and caspase-mediated apoptosis in ovarian cancer cells. RA-9 (5 μM; 0-24 hours) induces ER-stress responses in ovarian cancer cells. RA-9 (5 μM; over 24 hours) treatment results with time-dependent accumulation of the cleaved formed of PARP noticeable as early as 8 hours. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	RA-9 (5 mg/kg; i.p; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Coughlin K, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clin Cancer Res. 2014;20(12):3174-3186.

溶解度数据	In Vitro: DMSO : 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C)配制储备液

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