您当前的位置：

COR659

目录号: PL03660 纯度: ≥99%

COR659 是有效的 GABAB 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。

CAS No. :544450-68-2

商品编号	规格	价格	会员价
PL03660-5mg	5mg	¥828.00	请登录
PL03660-10mg	10mg	¥1315.00	请登录
PL03660-25mg	25mg	¥2045.00	请登录
PL03660-50mg	50mg	¥2765.00	请登录
PL03660-100mg	100mg	¥3845.00	请登录
PL03660-200mg	200mg	¥5165.00	请登录
PL03660-500mg	500mg	询价	询价
PL03660-10mM*1mLinDMSO	10mM*1mLinDMSO	¥5304.00	请登录
PL03660-1 mL x 10 mM (in DMSO)		¥636.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	COR659
英文名称	COR659
英文别名	Oprea1_692045;COR659;STK432329;ST50927516;2-(4-Chlorobenzoylamino)-4-ethyl-5-methylthiophene-3-carboxylic acid methyl ester;methyl 2-[(4-chlorophenyl)carbonylamino]-4-ethyl-5-methylthiophene-3-carboxyla te;methyl 2-{[(4-chlorophenyl)carbonyl]amino}-4-ethyl-5-methylthiophene-3-carboxylate
Cas No.	544450-68-2
分子式	C₁₆H₁₆ClNO₃S
分子量	337.82
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	COR659 是有效的 GABAB 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。

产品详情	COR659 是有效的 GABA_B 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。
生物活性	COR659 is a potent and effective GABA B positive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats.
性状	Solid
体外研究(In Vitro)	COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats. COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Paola Maccioni, et al. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA B and cannabinoid CB 1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543. [2]. Francesca Ferlenghi, et al. The GABA B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci.

溶解度数据	In Vitro: DMSO : 25 mg/mL (74.00 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

[1]. Paola Maccioni, et al. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA B and cannabinoid CB 1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543.
[2]. Francesca Ferlenghi, et al. The GABA B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

COR659

相关产品

The molarity calculator equation

The dilution calculator equation