COR659|544450-68-2|-陌孚医药/Medlife

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COR659

目录号: PL03660 纯度: ≥99%

CAS No. :544450-68-2

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中文名称	COR659
英文名称	COR659
英文别名	Oprea1_692045;COR659;STK432329;ST50927516;2-(4-Chlorobenzoylamino)-4-ethyl-5-methylthiophene-3-carboxylic acid methyl ester;methyl 2-[(4-chlorophenyl)carbonylamino]-4-ethyl-5-methylthiophene-3-carboxyla te;methyl 2-{[(4-chlorophenyl)carbonyl]amino}-4-ethyl-5-methylthiophene-3-carboxylate
Cas No.	544450-68-2
分子式	C₁₆H₁₆ClNO₃S
分子量	337.82
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	COR659 是有效的 GABA_B 的阳性变构调节剂 (PAM)。COR659 可缓解大鼠对酒精和巧克力的药物成瘾。
生物活性	COR659 is a potent and effective GABA B positive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats.
性状	Solid
体外研究(In Vitro)	COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats. COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Paola Maccioni, et al. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA B and cannabinoid CB 1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543. [2]. Francesca Ferlenghi, et al. The GABA B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci.

溶解度数据	In Vitro: DMSO : 25 mg/mL (74.00 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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