Tetrahydrodeoxycorticosterone|567-03-3|(Tetrahydro-11-deoxycorticosterone)-陌孚医药/Medlife

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Tetrahydrodeoxycorticosterone (Synonyms: Tetrahydro-11-deoxycorticosterone)

目录号: PL02144 纯度: ≥98%

CAS No. :567-03-3

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中文名称	Tetrahydrodeoxycorticosterone
中文别名	1-[2-氨基-1-(4-苄氧基苯基)乙基]环己醇盐酸盐;21-羟基孕烷醇酮;21-羟基孕烷醇酮标准品;21羟基孕烯醇酮
英文名称	Tetrahydrodeoxycorticosterone
英文别名	Pregnan-20-one,3,21-dihydroxy-, (3a,5b)-;Tetrahydro 11-Deoxycorticosterone;5B-PREGNAN-3A,21-DIOL-20-ONE;Tetrahydro 11-Deoxyc;TETRAHYDRODEOXYCORTICOSTERONE
Cas No.	567-03-3
分子式	C₂₁H₃₄O₃
分子量	334.49
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	Tetrahydrodeoxycorticosterone 是一种神经类固醇，是一种有效的 GABA_A 受体正变构调节剂 (PAM)。Tetrahydrodeoxycorticosterone 具有有效的神经抑制特性。
生物活性	Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABA A receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite
体外研究(In Vitro)	The endogenous neurosteroid Tetrahydrodeoxycorticosterone (THDOC) at physiological concentrations selectively enhances tonic currents mediated by αβδ receptors. In hippocampus, 10 nM Tetrahydrodeoxycorticosterone reduces neuronal excitability by augmenting tonic αβδ receptor currents. In thalamocortical neurons, although 100 nM Tetrahydrodeoxycorticosterone enhances tonic currents, 10 nM Tetrahydrodeoxycorticosterone does not. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Concentrations of Tetrahydrodeoxycorticosterone (THDOC) in brain tissue from mice with hepatic encephalopathy (HE) resulting from toxic liver injury are sufficient to induce sedation in animals of the same species. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300. [2]. Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7.

溶解度数据	In Vitro: DMSO : 100 mg/mL (298.96 mM; Need ultrasonic)配制储备液

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