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Aminooxyacetic acid hemihydrochloride

(Synonyms: 氨氧基乙酸半盐酸盐; Carboxymethoxylamine hemihydrochloride; Aminooxyacetate hemihydrochloride)

目录号: PL01643 纯度: ≥98%

Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride 是苹果酸-天冬氨酸穿梭 (MAS) 抑制剂, 也能抑制 GABA 降解酶 GABA-T。

CAS No. :2921-14-4

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中文名称	Aminooxyacetic acid hemihydrochloride
中文别名	羧甲基羟胺半盐酸盐;羧甲氧基胺半盐酸盐;羧基甲氧基胺半盐酸盐;AOA盐酸盐;Carboxymethoxylamine Hemihydrochloride 羧基甲氧基胺半盐酸盐;O-(羧甲基)羟胺半盐酸盐, 衍生化试剂;氨氧基乙酸盐;(氨氧基)乙酸半盐酸盐;O-羧甲基羟胺半盐酸盐;半盐酸羧甲氧基胺;羧甲基羟胺;(羧基甲氧基)胺半盐酸盐;羟胺-O-乙酸半盐酸盐;O-(羧甲基)羟胺半盐酸盐;(氨氧基)乙酸半盐酸盐;氨氧基乙酸半盐酸盐
英文名称	Aminooxyacetic acid hemihydrochloride
英文别名	2-(Aminooxy)acetic acid hydrochloride (2:1);(Aminooxy)acetic acid hemihydrochloride;Carboxymethoxylamine Hemihydrochloride;O-(Carboxymethyl)hydroxylamine hemihydrochloride;Aminooxyacetic Acid, Hydrochloride Salt;Carboxymethoxyamine Hemihydrochloride;(aminooxy)-aceticacihydrochloride(2:1);(carbomethoxy)amine hemihydrochloride;(carboxymethoxy)amine hemihydrochloride;2-aminooxyacetic acid;2-AMINOOXY-ACETICACIHYDROCHLORIDE;AMinooxyacetic acid Hydrochloride;Aminyloxy-acetic Acid Hemihydrochlorid;Carboxymethoxylamine-D2;O-(carboxymethyl) hydroxylamine hemichloride;Aminooxyacetic acid hemihydrochloride;Acetic acid, (aminooxy)-, hydrochloride (2:1);2-(Aminooxy)acetic acid hydrochloride(2:1);Acetic acid, 2-(aminooxy)-, hydrochloride (2:1);5G5QI2GN7A;bis(2-(aminooxy)acetic acid) hydrochloride;Aminooxyacetic acid hemichloride;EI;(Aminooxy)acetic Acid Hemihydrochloride;O-(Carboxymethyl)hydroxylamine Hemihydrochloride;Aminooxy-acetic acid hemihydrochloride
Cas No.	2921-14-4
分子式	C₄H₁₁ClN₂O₆
分子量	218.59
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride 是苹果酸-天冬氨酸穿梭 (MAS) 抑制剂, 也能抑制 GABA 降解酶 GABA-T。

产品详情	Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride 是苹果酸-天冬氨酸穿梭 (MAS) 抑制剂, 也能抑制 GABA 降解酶 GABA-T。
生物活性	Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
性状	Solid
IC50 & Target[1][2]	MAS, GABA-T
体外研究(In Vitro)	Aminooxyacetic acid hemihydrochloride (AOAA) dose-dependently decreases the survival of C6 glioma cells. Aminooxyacetic acid hemihydrochloride treatment produces a significant increase in the percentage of the cells arrested in the stage of G0/G1, as well as a significant decrease in the percentage of the cells at S phase and G2/M phase. Aminooxyacetic acid hemihydrochloride treatment leads to an obvious decrease in the number of the cells in the phase of cell division. Aminooxyacetic acid hemihydrochloride significantly increases the percentage of the cells in both early-stage apoptosis and necrosis. Treatment of the cells with 1?mM or 5?mM Aminooxyacetic acid hemihydrochloride leads to decreased levels of aging of the cells. Glutamine-dependent cell lines show greater inhibition of cell growth by Aminooxyacetic acid hemihydrochloride (AOA) compare with cells that are less g
体内研究(In Vivo)	The accumulation of GABA in cerebellum and whole brain is initially very rapid, being significantly increased already 5 min after the injection of Aminooxyacetic acid hemihydrochloride (AOAA). The rapid initial accumulation becomes gradually slower and maximal levels (400 to 600 % of the control levels) are reached 2 to 6 h after Aminooxyacetic acid hemihydrochloride. Still 24 h after Aminooxyacetic acid hemihydrochloride the GABA levels are elevated by about 250%. From 2 to 6 h after Aminooxyacetic acid hemihydrochloride the convulsions are completely blocked. Twenty four hours after Aminooxyacetic acid hemihydrochloride the convulsions are almost identical to the controls. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378(1):1-7. [2]. Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):210-5.

溶解度数据	In Vitro: H₂O : 100 mg/mL (914.91 mM; Need ultrasonic)DMSO : 42.9 mg/mL (392.50 mM; Need ultrasonic and warming)配制储备液

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[1]. Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378(1):1-7.
[2]. Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):210-5.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Aminooxyacetic acid hemihydrochloride

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