Pivagabine

(Synonyms: CXB-722)
目录号: PL01659 纯度: ≥99%
Pivagabine (CXB 722) 是具有神经调节活性的疏水性4-氨基丁酸衍生物。Pivagabine 能穿透大鼠的血脑屏障。Pivagabine 拮抗足部休克对大鼠脑内 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
CAS No. :69542-93-4
商品编号 规格 价格 会员价 是否有货 数量
PL01659-5mg 5mg ¥174.00 请登录
PL01659-10mg 10mg ¥284.00 请登录
PL01659-25mg 25mg ¥574.00 请登录
PL01659-50mg 50mg ¥923.00 请登录
PL01659-100mg 100mg ¥1475.00 请登录
PL01659-1 mL x 10 mM (in DMSO) 1 mL x 10 mM (in DMSO) ¥164.00 请登录
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中文名称
Pivagabine
中文别名
匹伐加宾
英文名称
Pivagabine
英文别名
4-Pivalamidobutanoic acid;4-(2,2-dimethylpropanoylamino)butanoic acid;4-[(2,2-dimethylpropanoyl)amino]butanoic acid;Butanoic acid,4-[(2,2-dimethyl-1-oxopropyl)amino]-;4-((2,2-Dimethylpropionyl)amino)butyric acid;4-Pivalamidobutyric acid;Butanoic acid, 4-((2,2-dimethyl-1-oxopropyl)amino)-;N-Trimethylacetyl-4-aminobutyric acid;Pivagabine [INN];UNII-C53SV0WO4V;CXB 722;PG 2;PG 2 (pharmaceutical);Tonerg;Pivagabine
Cas No.
69542-93-4
分子式
C9H17NO3
分子量
187.24
包装储存
Powder -20°C 3 years;4°C 2 years
详情描述

Pivagabine (CXB 722) 是具有神经调节活性的疏水性4-氨基丁酸衍生物。Pivagabine 能穿透大鼠的血脑屏障。Pivagabine 拮抗足部休克对大鼠脑内 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。

产品详情
Pivagabine (CXB 722) 是具有神经调节活性的疏水性4-氨基丁酸衍生物。Pivagabine 能穿透大鼠的血脑屏障。Pivagabine 拮抗足部休克对大鼠脑内 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
生物活性
Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.
性状
Solid
体内研究(In Vivo)
Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
ClinicalTrial
参考文献
[1]. Esposito G, et al. Pivagabine: a novel psychoactive drug. Arzneimittelforschung. 1997 Nov;47(11A):1306-9.
[2]. Serra M, et al. Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain. Psychoneuroendocrinology. 1999 Apr;24(3):269-84.
溶解度数据
In Vitro: DMSO : 50 mg/mL (267.04 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Esposito G, et al. Pivagabine: a novel psychoactive drug. Arzneimittelforschung. 1997 Nov;47(11A):1306-9.
[2]. Serra M, et al. Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain. Psychoneuroendocrinology. 1999 Apr;24(3):269-84.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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