Methionine|348-67-4|(D-蛋氨酸; MRX-1024; D-Methionine)-陌孚医药/Medlife

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Methionine (Synonyms: D-蛋氨酸; MRX-1024; D-Methionine)

目录号: PL03646 纯度: ≥99%

CAS No. :348-67-4

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中文名称	Methionine
中文别名	D-蛋氨酸;D-2-氨基-4-甲硫基丁酸;D-甲硫氨酸;D-Methionine D-蛋氨酸;D-蛋氨酸 D-Methionine;D-蛋氨酸,D-Methionine;D-蛋氨酸及合成技术;D-甲硫氨基酸;D-甲硫氨酸,D-2-氨基-4-甲硫基丁酸;D-甲硫基丁氨酸
英文名称	Methionine
英文别名	D-Methionine;(r)-2-amino-4-(methylmercapto)butyric acid;d-2-amino-4-(methylthio)butyric acid;MRX-1024;(2R)-2-amino-4-methylsulfanylbutanoic acid;H-D-Met-OEt.HCl;H-D-Met-OH;(R)-2-Amino-4-(methylmercapto)butyric acid (D-2-Amino-4-(methylthio)butanoic acid;D-Methionin;R-Methionine;D-2-Amino-4-(methylthio)butanoic acid;(R)-Methionine;methionine;D-Metionien;METHIONINE, D-;(R)-2-amino-4-(methylthio)butanoic acid;(2R)-2-amino-4-(methylsulfanyl)butanoic acid;Methionine D-;FFEARJCKVFRZRR-SCSAIBSYSA-N;MED;D-Metionien [Australian];868496F25R;L-Methio;(R)-2-Amino-4-(methylmercapto)butyric acid;D-2-Amino-4-(methylthio)butyric acid
Cas No.	348-67-4
分子式	C₅H₁₁NO₂S
分子量	149.21
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Methionine (MRX-1024; D-Methionine) 是一种有效的化学保护剂，它还可以通过激活 GABA_A 受体来抑制神经元活性。

生物活性

Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABA A receptor activation.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1:1 complex that is followed by the formation of a 2:1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01) while not significantly different from controls or from animals treated only with D-methionine (P>0.05). When Methionine is administered alone the average cell density is 0.95±0.099 (SEM) and not significantly different from controls (P>0.05). has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93.
[2]. Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6(3):532-41.

溶解度数据	In Vitro: H₂O : 25 mg/mL (167.55 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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