Inarigivir ammonium|2172788-92-8|(ORI-9020 ammonium; SB-9000 ammonium)-陌孚医药/Medlife

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Inarigivir ammonium (Synonyms: ORI-9020 ammonium; SB-9000 ammonium)

目录号: PL01316 纯度: ≥99%

CAS No. :2172788-92-8

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中文名称	Inarigivir ammonium
英文名称	Inarigivir ammonium
英文别名	Inarigivir (ammonium);Inarigivir ammonium
Cas No.	2172788-92-8
分子式	C₂₀H₂₉N₈O₁₀PS
分子量	604.53
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Inarigivir (ORI-9020) ammonium 是一种二核苷酸抗病毒化合物，可显着减少表达乙型肝炎病毒转基因小鼠的 HBV DNA。Inarigivir (ORI-9020) 是维甲酸诱导基因-I (RIG-I) 的激动剂，可激活细胞内的先天免疫。

生物活性

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses.

性状

Solid

IC50 & Target[1][2]

Target: HBV.

体外研究(In Vitro)

Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Iyer RP, et al. Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model. Antimicrob Agents Chemother. 2004 Jun;48(6):2318-20.
[2]. Danni Colledge, et al. The Novel Antiviral Agent Inarigivir Inhibits Both Nucleos(t)ide Analogue and Capsid Assembly Inhibitor Resistant HBV in vitro.

溶解度数据	In Vitro: H₂O : 100 mg/mL (165.42 mM; Need ultrasonic)DMSO : 100 mg/mL (165.42 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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