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Punicalagin

(Synonyms: 安石榴甙)

目录号: PC58229 纯度: ≥99%

Punicalagin是一种从Punica granatum L.或Terminalia catappa L.的叶子中分离的多酚成分。

CAS No. :65995-63-3

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中文名称	Punicalagin
中文别名	安石榴苷;安石榴甙;安石榴甙（安石榴苷）;安石榴苷(安石榴甙);安石榴苷,Punicalagin,植物提取物,标准品,对照品;安石榴苷、安石榴甙;安石榴苷Punicalagin;安石榴苷对照品;石榴皮提取物
英文名称	Punicalagin
英文别名	Punicalagin;Punicalagins;PUNICALAGINS A&B(P);B(P);PULCHINENOSIDE B4(RG);PUNICALAGINS A&D-Glucose,cyclic4,6-[2,2'-(5,10-dihydro-2,3,7,8-tetrahydroxy-5,10-dioxo[1]benzopyrano[5,4,3-cde][1]benzopyran-1,6-diyl)bis[3,4,5-trihydroxybenzoate]]cyclic 2,3-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate),[2(S),4(S,S)]-;2,20,1,23-(Epoxy[2]propene[1,2]diyl[3]ylidene)-11H,15H-tribenzo[g,i,q][1,5,12]trioxacyclononadecin,D-glucose deriv.;Dibenzo[f,h][1,4]dioxecin, D-glucose deriv.;D-Glucose,cyclic 4,6-[(S,S)-2,2'-(5,10-dihydro-2,3,7,8-tetrahydroxy-5,10-dioxo[1]benzopyrano[5,4,3-cde][1]benzopyran-1,6-diyl)bis[3,4,5-trihydroxybenzoate]]cyclic 2,3-[(S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate];D-Glucose, cyclic4,6-[(2S,2'S)-2,2'-(5,10-dihydro-2,3,7,8-tetrahydroxy-5,10-dioxo[1]benzopyrano[5,4,3-cde][1]benzopyran-1,6-diyl)bis[3,4,5-trihydroxybenzoate]]cyclic 2,3-[(S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate];BDBM50377922;N1687;(1R,35R,37R,38R,55S)-6,7,8,11,12,23,24,27,28,29,37,43,44,45,48,49,50-Heptadecahydroxy-2,14,21,33,36,;(1R,35R,37R,38R,55S)-6,7,8,11,12,23,24,27,28,29,37,43,44,45,48,49,50-heptadecahydroxy-2,14,21,33,36,
Cas No.	65995-63-3
分子式	C₄₈H₂₈O₃₀
分子量	1084.72
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
详情描述	Punicalagin是一种从Punica granatum L.或Terminalia catappa L.的叶子中分离的多酚成分。 Punicalagin是一种可逆且非竞争性的3CL^pro抑制剂，在体外可抑制SARS-CoV-2复制。Punicalagin是一种抗乙型肝炎病毒(HBV)药物，具有抗氧化，抗炎和抗癌作用。Punicalagin 有潜力用于COVID-19的研究。

生物活性

Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19.

性状

Solid

体外研究(In Vitro)

Punicalagin (100 mg/ml) induces apoptosis in HT-29, HCT116 colon cells.
Punicalagin slightly inhibits the PL activity with an IC50 of over 50 μM. Punicalagin inhibits the plaque formation of SARS-CoV-2 in a dose-dependent manner, with EC50 values of 7.20 μM.
Punicalagin binds at an allosteric site in the dimer interface. Punicalagin inhibit SARS-CoV-2 replication by a mechanism other than preventing S-mediated viral entry.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Punicalagin (10 mg/kg) inhibits the edema rate of 58.15% in rats.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

ClinicalTrial

结构分类

Phenols
Polypheno

来源

Plants

溶解度数据	体外研究: DMSO : 50 mg/mL(46.09 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Punicalagin

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