Doxorubicin HCl

盐酸阿霉素;(8S-cis)-10-[(3-氨基-2,3,6-三去氧-a-L-来苏己吡喃基)-氧]-7,8,9,10-四氢-6,8,11-三羟基-8-羟基乙酰基-1-甲氧基-5,12-并四苯二酮盐酸盐;盐酸多柔比星;盐酸柔红霉素;14-羟正定霉素;阿得里亚霉素;阿霉素盐酸盐;亚德里亚霉素盐酸盐;盐酸亚德里亚霉素;亚德里亚霉素,阿霉素(盐酸盐);盐酸阿霉;盐酸多柔比星,阿霉素;12-萘二酮的盐酸盐;Doxorubicin Hydrochloride 盐酸多柔比星;Doxorubicin hydrochloride 盐酸阿霉素;阿霉素;阿霉素-13C-D3盐酸;阿霉素盐酸盐 ,Doxorubicin hydrochloride;羟基柔红霉素盐酸盐;盐酸阿霉素 (盐酸多柔比星);盐酸阿霉素 EP标准品;盐酸阿霉素 标准品;盐酸阿霉素 盐酸多柔比星;盐酸阿霉素、盐酸多柔比星;盐酸多柔比星 Doxorubicin HCl;盐酸多柔比星 USP标准品;盐酸多柔比星(比星类);盐酸多柔比星Doxorubicin hydrochloride;盐酸多柔比星标准品;盐酸多柔吡星;盐酸羟基柔红霉素;盐酸阿霉素,阿霉素;盐酸多柔比星,盐酸柔红霉素,阿得里亚霉素,14-羟正定霉素,阿霉素;多柔比星® 盐酸盐;羟基柔红霉素 盐酸盐

Doxorubicin Hydrochloride

doxorubicin hydrochloride;Doxorubicin, HCl;(8s-cis)-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;DOX;ADRIAMYCIN, HYDROCHLORIDE;Doxorubicin (Adriamycin);Doxorubicin (hydrochloride);Doxorubicin hydrochloride (Adriamycin®, Adriamycin PFS®, Adriamycin RDF®, Rubex®,Adriacin®, Adriblastin®,Adriblastina®,Caelyx®, Doxil®,Farmiblastina®,Lipodox®, Myocet®);Doxorubicin;14-hydroxydaunomycin hydrochloride;ADR;ADRIACIN;Adriamycin;Ardriamycin;Caely;CAELYX;DOX HCl;Dox hydrochloride;DOX,Hydroxydaunorubicin hydrochloride;Doxorubicin (Adriamycin) HCl;FI 106;fi6804;Hydroxydaunorubicin hydrochloride;Lipodox;(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;Doxorubicin HCl;Adriblastina;Rubex;ADRIAMYCIN HYDROCHLORIDE;Adriamycin RDF;Adriamycin PFS;Adriblastin;MLS001401460;82F2G7BL4E;Resmycin;Hydroxydaunorubicin;SMR000058570;CPD000058570;DSSTox_RID_78854;DSSTox_CID_10636;DSSTox_RID_80678;DSSTox_GSID_30636;DSSTox_GSID_45111;CAS-NOCAS_;Doxorubicin hydrochloride

25316-40-9

C₂₇H₂₉NO₁₁

543.50

Doxorubicin hydrochloride是一种具有细胞毒性和抗肿瘤活性的蒽环类抗生素，是人类DNA拓扑异构酶I和II的有效抑制剂，IC50分别为0.8 μM和2.67 μM。它不仅能够降低AMPK及其下游靶蛋白乙酰辅酶A羧化酶的磷酸化，还可诱导细胞发生凋亡和自噬。在动物实验中，Doxorubicin hydrochloride常被用于诱导急性肾衰竭、慢性肾损伤以及心力衰竭模型。