L-DABA (L-2,4-Diaminobutyric acid)是GABA转氨酶的弱抑制剂，IC₅₀ 值大于500 μM。在体内和体外具有抗肿瘤活性。

L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC 50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

Solid

Human Endogenous Metabolite

The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and

Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

Ketones, Aldehydes, Acids

[1]. Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96(3):259-68.
[2]. Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5(3-4):193-8.
[3]. Panasci L, et al. The cytolytic ef

In Vitro: H₂O : 1 mg/mL (8.47 mM; Need ultrasonic)配制储备液