KDM5-IN-1|1628210-26-3|-陌孚医药/Medlife

您当前的位置：

KDM5-IN-1

目录号: PL15110 纯度: ≥99%

CAS No. :1628210-26-3

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	KDM5-IN-1
中文别名	KDM5-IN-1
英文名称	KDM5-IN-1
英文别名	KDM5-IN-1;5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;5-[1-(1,1-Dimethylethyl)-1H-pyrazol-4-yl]-4,7-dihydro-6-(1-methylethyl)-7-oxo-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;KDM5 inhibitor compound 48;BDBM50158830;5-(1-(tert-butyl)-1H-pyrazol-4-yl)-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;5-(1-tert-Butyl-1H-pyrazol-4-yl)-
Cas No.	1628210-26-3
分子式	C₁₇H₂₀N₆O
分子量	324.38
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	KDM5-IN-1是高效选择，有口服活性的KDM5抑制剂，IC₅₀值为15.1 nM。
生物活性	KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC 50 of 15.1 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 15.1 nM (KDM5); EC50: 0.34 μM (PC9 H3K4Me3)
体外研究(In Vitro)	KDM5-IN-1 is found to potently inhibit KDM5B and KDM5C isoforms (IC50 of 4.7 and 65.5 nM, respectively). It is significantly less potent against other KDM enzymes (1A, 2B, 3B, 4C, 5A, 6A, 7B), inhibiting KDM4C the strongest with an IC50 of 1.9 μM. KDM5-IN-1 still displays more than 100-fold selectivity for KDM4C vs. KDM5A. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	When dosed orally in mice at 50 mg/kg twice a day, KDM5-IN-1 shows an unbound maximal plasma concentration C max >15-fold over its cell EC 50 , thereby providing a robust chemical probe for studying KDM5 biological functions in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Liang J, et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41.

溶解度数据	In Vitro: DMSO : ≥ 30 mg/mL (92.48 mM)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品