GSK2879552 dihydrochloride|1902123-72-1|-陌孚医药/Medlife

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GSK2879552 dihydrochloride

目录号: PL15107 纯度: ≥99%

CAS No. :1902123-72-1

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PL15107-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1559.00	请登录

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中文名称	GSK2879552 dihydrochloride
英文名称	GSK2879552 dihydrochloride
英文别名	GSK2879552 Dihydrochloride;GSK2879552 dihydrochloride
Cas No.	1902123-72-1
分子式	C₂₃H₂₈Cl₂N₂O₂
分子量	435.39
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

GSK2879552 dihydrochloride是一种可口服的，不可逆的 LSD1/ KDM1A 抑制剂，具有抗肿瘤活性。

生物活性

GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity.

性状

Solid

体外研究(In Vitro)

GSK2879552 inhibits KDM1A histone demethylase activity, inducing differentiation of sorafenib-resistant cells and attenuates stemness properties. GSK2879552 depresses the transcription of Wnt antagonists and downregulates β-catenin signaling activity in sorafenib-resistant cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay.

体内研究(In Vivo)

GSK2879552 (1.5 mg/kg, p.o.) treatment exhibits tumor growth inhibition in SCLC xenograft bearing mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NCI-H526 and NCI-H1417 xenograf

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Huang M, et al. Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma. Cancer Lett. 2017 Apr 2;398:12-21.
[2]. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.

溶解度数据	In Vitro: H₂O : 100 mg/mL (228.62 mM; Need ultrasonic)DMSO : 31.25 mg/mL (71.44 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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