Virodhamine 是一种内源性大麻素，它通过激活大麻素 (CB) 受体调节神经传递。Virodhamine 是 CB1 受体的拮抗剂和 CB2 受体的激动剂。Virodhamine 通过触发 MAPK 信号和 ROS 的产生诱导巨核细胞分化。 Virodhamine 可用于治疗各种神经疾病，如阿尔茨海默病和帕金森。

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimers and Parkinsons diseases.

Viscous liquid

Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus.
Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1.
Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control.
Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells. has not independently confirmed the accuracy of these methods. They are for reference only.

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ICR mice w

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Pure form -20°C 3 years；4°C 2 years

[1]. Sharma DS, et al. Virodhamine, an endocannabinoid, induces megakaryocyte differentiation by regulating MAPK activity and function of mitochondria. J Cell Physiol. 2021 Feb;236(2):1445-1453.
[2]. Hayase T. Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors. BMC Neurosci. 2013 Feb 9;14:20.

In Vitro: DMSO : ≥ 100 mg/mL (287.74 mM)配制储备液