Rimonabant-d10 (hydrochloride)|1044909-61-6|(盐酸利莫那班 d-陌孚医药/Medlife

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Rimonabant-d10 (hydrochloride) (Synonyms: 盐酸利莫那班 d

目录号: PL13537

CAS No. :1044909-61-6

商品编号	规格	价格	会员价	是否有货	数量
PL13537-1mg	1mg	询价	询价
PL13537-10mg	10mg	询价	询价

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中文名称	Rimonabant-d10 (hydrochloride)
中文别名	[ 2H10 ] - 盐酸利莫那班标准品;氘代盐酸利莫那班;[2H10]-盐酸利莫那班
英文名称	Rimonabant-d10 (hydrochloride)
英文别名	[2H10]-Rimonabant hydrochloride;Rimonabant-d10 Hydrochloride;5-(4-chlorophenyl)-N-(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide:hydrochloride;Rimonabant hydrochloride salt
Cas No.	1044909-61-6
分子式	C₂₂H₂₂Cl₄N₄O
分子量	510.31
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Rimonabant-d₁₀ (hydrochloride) 是 Rimonabant Hydrochloride 的氘代物。Rimonabant hHydrochloride (SR 141716A Hydrochloride) 是中心大麻素受体 1 (CB1) 高效的、选择性的反向激动剂， K_i 值为1.8 nM。Rimonabant hHydrochloride (SR 141716A Hydrochloride) 也能够抑制分枝杆菌膜蛋白3 (MMPL3)。
生物活性	Rimonabant-d 10 (hydrochloride) is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):905-15.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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