LY2828360 是一个作用缓慢但很有效的 G 蛋白偏倚的大麻素受体 2 (CB₂) 激动剂，能够抑制 cAMP 的积累并激活 ERK1/2 通路。

LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB 2 ) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

Solid

CB2.

In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical and cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical and cold hypersensitivities and suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB 2 KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical and cold allodynia in WT mice but not in CB 2 KO mice previously rende

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Lin X, et al. Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. Mol Pharmacol. 2018 Feb;93(2):49-62.

In Vitro: DMSO : 20.83 mg/mL (48.79 mM; Need ultrasonic)配制储备液