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Fluvoxamine maleate

(Synonyms: 马来酸氟伏沙明; DU-23000 maleate)

目录号: PL11262 纯度: ≥99%

Fluvoxamine maleate (DU-23000 maleate) 是5-羟色胺再吸收抑制剂，有抗抑郁活性。

CAS No. :61718-82-9

商品编号	规格	价格	会员价
PL11262-10mg	10mg	¥284.00	请登录
PL11262-50mg	50mg	¥1542.00	请登录
PL11262-100mg	100mg	¥991.00	请登录
PL11262-200mg	200mg	¥1465.00	请登录
PL11262-500mg	500mg	¥2485.00	请登录
PL11262-10mM*1mLinDMSO	10mM*1mLinDMSO	¥803.00	请登录
PL11262-1 mL x 10 mM (in DMSO)		¥272.00	请登录

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中文名称	Fluvoxamine maleate
中文别名	马来酸氟伏沙明;(E)-5-甲氧基-1-(4-三氟甲苯基)-O-(2-胺乙肟基)-1-戊酮马来酸盐;Fluvoxamine Maleate 马来酸氟伏沙明;氟伏沙明系统适应性 EP标准品;马来酸氟伐沙明;马来酸氟伏沙明 EP标准品;马来酸氟伏沙明 USP标准品;马来酸氟伏沙明,AR;马来酸氟伏沙明标准品;马来酸氟伏沙明标准品(JP);马来酸氟伏沙明杂质标准;马来酸氟戊肟胺;(E)-5-甲氧基-1-[4-(三氟甲基)苯基]-O-(2-胺乙肟基)-1-戊酮马来酸盐;(E)-5-甲氧基-4-三氟甲基苯戊酮-O-(2-氨乙基)肟马来酸盐;伏氟沙明马来酸盐;马来酸氟;氟伏沙明马来酸盐
英文名称	Fluvoxamine maleate
英文别名	(E)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one O-(2-aminoethyl) oxime maleate;1-Pentanone, 5-methoxy-1-(4-(trifluoromethyl)phenyl)-, O-(2-aminoethyl)oxime, (Z)-2-butenedioate (1:1);5-Methoxy-4'-trifluoromethylvalerophenone (E)-O-2-aminoethyloxime monomaleate;(E)-Fluvoxamine Maleate;Fluvoxamine (maleate);Fluvoxamine maleate;(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone 2-aminoethyloxime maleate;(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-2-aminoethyl oxime (Z)-but-2-enedoic acid salt;(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-2-aminoethyl oxime maleate;Dumirox;Faverin;faverin50;Fevarin;Floxyfral;Fluvoxamine Maleat;Luvox;Maveral;MK-264;(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate;(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate;(Z)-But-2-enedioic acid;1,1,2,2-tetradeuterio-2-[(Z)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentyli;(Z)-But-2-enedioic acid;1,1,2,2-tetradeuterio-2-[(Z)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine;Fluvoxamine Maleate
Cas No.	61718-82-9
分子式	C₁₉H₂₅F₃N₂O₆
分子量	438.43
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Fluvoxamine maleate (DU-23000 maleate) 是5-羟色胺再吸收抑制剂，有抗抑郁活性。

产品详情

Fluvoxamine maleate (DU-23000 maleate) 是5-羟色胺再吸收抑制剂，有抗抑郁活性。

生物活性

Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

性状

Solid

IC50 & Target[1][2]

SSRIs.

体内研究(In Vivo)

Fluvoxamine maleate (DU-23000 maleate) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol wa

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Ginsburg, B.C., J.W. Pinkston, and R.J. Lamb, The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food. Behav Pharmacol, 2012. 23(2): p. 134-42.
[2]. Claassen, V., et al., Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br J Pharmacol, 1977. 60(4): p. 505-16.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (230.20 mM)H₂O : 20 mg/mL (46.04 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Fluvoxamine maleate

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