Fluoxetine hydrochloride (Synonyms: 盐酸氟西汀; LY 110140)
目录号: PL09258 纯度: ≥99%
CAS No. :56296-78-7
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中文名称
Fluoxetine hydrochloride
中文别名
盐酸氟西汀;(+/-)-N-甲基-3-(对三氟甲基苯氧基)-3-苯基丙胺盐酸盐;Fluoxetine Hydrochloride 盐酸氟西汀;氟西汀;氟西汀盐酸盐;氟西汀盐酸盐 标准品;盐酸氟西汀 标准品;盐酸氟西汀杂质;弗洛克叮盐酸盐;(±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯基丙胺 盐酸盐;LY-110,140 盐酸盐
英文名称
Fluoxetine hydrochloride
英文别名
Fluoxetine hydrochloride;Methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amine hydrochloride;Fluoxetine HCl;Fluoxetine (hydrochloride);Fluoxetine hydrochloride (LY110140 hydrochloride, Prozac®, Sarafem®, Ladose® and Fontex®);LY-110140;Adofen-d5;Ansilan-d5;Fluctin-d5;fluoxetine hydrogen chloride;fontex;Fontex-d5;Foxetin-d5;Lovan-d;Lovan-d5;LY110140;Zepax-d5;Prozac®;N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine Hydrochloride;N-Methyl-gama-[4-(trifluoromethyl);Prozac;Sarafem;Fluoxeren;Fluctin;Adofen;Lovan;Rowexetina;Modipran;Foxetin;Flutine;Fluctine;Proctin;Deproxin;Fluoxac;Flunirin;Pragmaten;Margrilan;Fluoxil;Flufran;Digassim;Affectine;Sanzur;Zactin;Fluxil;Flunil;Oxedep;Nopres;Neupax;Erocap;Sinzac;Prodep;Prizma;Lorien;Fluxen;Flutin;Fludac;Zepax;Nuzak;Fluox-Puren;Prozac 20;Alzac 20;Fluoxetine.HCl;Lilly 110140;Selfemra;Reconcile;Prozac W;LY 110140
Cas No.
56296-78-7
分子式
C17H19ClF3NO
分子量
345.79
包装储存
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
产品详情
Fluoxetine hydrochloride (LY 110140) 是抗抑郁药和选择性的血清素重吸收抑制剂。
生物活性
Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor.
性状
Solid
体外研究(In Vitro)
Fluoxetine hydrochloride (LY 110140) blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. has not independently confi
体内研究(In Vivo)
Fluoxetine hydrochloride (LY 110140) treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献
[1]. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71
[2]. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80.
溶解度数据
In Vitro: DMSO : ≥ 25 mg/mL (72.30 mM)H2O : 10 mg/mL (28.92 mM; Need ultrasonic)
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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