SLIGRL-NH2|171436-38-7|(Protease-Activated Receptor-2 Activating Peptide)-陌孚医药/Medlife

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SLIGRL-NH2 (Synonyms: Protease-Activated Receptor-2 Activating Peptide)

目录号: PL10708 纯度: ≥99%

CAS No. :171436-38-7

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PL10708-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4413.00	请登录

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中文名称	SLIGRL-NH2
英文名称	SLIGRL-NH2
英文别名	L-Leucinamide,L-seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-;SLIGRL-NH2;PAR-2 (1-6) amide (mouse, rat);SER-LEU-ILE-GLY-ARG-LEU-NH2;SLIGRL-NH2;H2N-SLIGRL-AMIDE;H-SER-LEU-ILE-GLY-ARG-LEU-NH2;PAR2-AP;REF DUPL: H-Ser-Leu-Ile-Gly-Arg-Leu-NH2;SER-LEU-ILE-GLY-ARG-LEU-AMIDE;SLIGRLAMIDE;PAR2-AP, SLIGRL-NH2
Cas No.	171436-38-7
分子式	C₂₉H₅₆N₁₀O₇
分子量	656.82
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) 是一种蛋白酶激活受体-2 (PAR-2) 激动剂。
生物活性	SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2).
性状	Solid
IC50 & Target[1][2]	PAR-2
体外研究(In Vitro)	SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 μM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 μM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)]. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	SLIGRL-NH2
Sequence	Ser-Leu-Ile-Gly-Arg-Leu-NH2
参考文献	[1]. Akiyama T, et al. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlativeresponses of lumbar dorsal horn neurons in the mouse. Neuroscience. 2014 Apr 25;266:38-46. [2]. Li Y, et al. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. Br J Pharmacol. 2011 Dec;164(8):1990-2002.

溶解度数据	In Vitro: H₂O : 110 mg/mL (167.47 mM; Need ultrasonic)DMSO : 100 mg/mL (152.25 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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