TRAP-6|141136-83-6|(PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6)-陌孚医药/Medlife

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TRAP-6 (Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6)

目录号: PL10709 纯度: ≥99%

CAS No. :141136-83-6

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中文名称	TRAP-6
中文别名	凝血酶受体激活肽6;对乙基苯磺酰胺;肽6凝血酶受体活化剂(TRAP-6);SER-PHE-LEU-LEU-ARG-ASN
英文名称	TRAP-6
英文别名	L-Asparagine,L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-;SER-PHE-LEU-LEU-ARG-ASN;THROMBIN RECEPTOR ACTIVATOR FOR PEPTIDE 6 (TRAP-6);Thrombin Receptor Activator Peptide 6;TRAP-6;(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoic acid;Thrombin receptor (42-47), human;SFLLRN;SFLLRN-OH;BDBM85086;Thrombin Receptor Activator Peptide 6, >95% (HPLC);Ser-Phe-Leu-Leu-Arg-Asn;Thrombin Receptor Activator Peptide 6;L-Seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparagine
Cas No.	141136-83-6
分子式	C₃₄H₅₆N₁₀O₉
分子量	748.87
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	TRAP-6 (PAR-1 agonist peptide)，一种多肽片段，是选择性的蛋白酶激活受体 1 (PAR1) 激动剂。TRAP-6 通过凝血酶受体激活人血小板。TRAP-6 对 PAR4 无活性。
生物活性	TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.
性状	Solid
IC50 & Target[1][2]	PAR1
体外研究(In Vitro)	TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1. TRAP-6 (0.01-10 μM; 30 min) activates human platelets. TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	SFLLRN
Sequence	Ser-Phe-Leu-Leu-Arg-Asn
参考文献	[1]. Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. [2]. Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82(1):103-6.

溶解度数据	In Vitro: H₂O : 25 mg/mL (33.38 mM; Need ultrasonic)配制储备液

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