ATX inhibitor 5|2402772-45-4|-陌孚医药/Medlife

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ATX inhibitor 5

目录号: PL09720 纯度: ≥99%

CAS No. :2402772-45-4

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产品详情	ATX inhibitor 5 是有效的口服活性 autotaxin (ATX) 抑制剂，IC₅₀ 为 15.3 nM。AATX inhibitor 5 具有抗肝纤维化作用，并显着降低 CCl4 诱导的肝纤维化水平。
生物活性	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC 50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently.
性状	Solid
IC50 & Target[1][2]	Autotaxin
体外研究(In Vitro)	ATX inhibitor 5 (compound 10g) (IC50s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC). ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay
体内研究(In Vivo)	ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Konmin mice
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Jiang N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem. 2020 Feb 1;187:111904.

溶解度数据	In Vitro: DMSO : 250 mg/mL (526.46 mM; Need ultrasonic)配制储备液

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