Pentoxifylline-d5|1185995-18-9|(BL-191-d-陌孚医药/Medlife

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Pentoxifylline-d5 (Synonyms: BL-191-d

目录号: PL09735 纯度: ≥99%

CAS No. :1185995-18-9

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中文名称	Pentoxifylline-d5
中文别名	3,7-二氢-3,7-二甲基-1-(5-氧代己基-4,4,6,6,6-五氘代)-1H-嘌呤-2,6-二酮;己酮可可碱-4′,4′,6′,6′,6′-d5;己酮可可碱-D5;己酮可可碱-D5氘代内标;己酮可可碱-D5(己酮可可碱杂质17);己酮可可碱 d5
英文名称	Pentoxifylline-d5
英文别名	3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl-4,4,6,6,6-d5)-1H-purine-2,6-dione;283.34;3,7-dimethyl-1-(4,4,6,6,6-d5-5-oxohexyl)-1H-purine2,6(3H,7H)-dione;Pentoxifylline-d5;Pentoxyfylline-D5;Pentoxifylline D5Q: What is Pentoxifylline D5 Q: What is the CAS Number of Pentoxifylline D5 Q: What is the storage condition of Pentoxifylline D5 Q: What are the applications of Pentoxifylline D5;Pentoxifylline-d
Cas No.	1185995-18-9
分子式	C₁₃H₁₈N₄O₃
分子量	278.31
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Pentoxifylline-d₅ 是 Pentoxifylline 的氘代物。Pentoxifylline (BL-191) 是一种血液流变学改善剂。Pentoxifylline 是一种具有口服活性的，非选择性的磷酸二酯酶 (PDE) 抑制剂，具有免疫调节、抗炎、血液流变学改善、抗纤溶和抗增殖作用。Pentoxifylline 可用于研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
生物活性	Pentoxifylline-d 5 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Iffat Hassan, et al. Pentoxifylline and its applications in dermatology. Indian Dermatol Online J. 2014 Oct-Dec; 5(4): 510–516. [3]. A Ward, et al. Pentoxifylline. A review

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (352.93 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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