Senazodan hydrochloride|98326-33-1|(MCI 154 hydrochloride)-陌孚医药/Medlife

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Senazodan hydrochloride (Synonyms: MCI 154 hydrochloride)

目录号: PL09678 纯度: ≥99%

Senazodan (MCI 154) (hydrochloride) 是一种 Ca²⁺ 感光剂，同时可抑制 PDE III 的活性。

CAS No. :98326-33-1

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中文名称	Senazodan hydrochloride
中文别名	司那佐旦(盐酸盐)
英文名称	Senazodan hydrochloride
英文别名	MCI 154;6-[4-(4-Pyridinylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hyd rochloride (1:1);Senazodan hydrochloride;8AQJ5MIM3P;6-(4-(4'-Pyridyl)aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride;3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(4-pyridinylamino)phenyl)-, monohydrochloride;4,5-Dihydro-6-(4-(4-pyridinylamino)phenyl)-3(2H)-pyridazinone monohydrochloride;C15H14N4O.HCl;Q27270120;6-[4-(pyridin-4-ylamino)phenyl]-4,5-dihydro-2H-pyridazin-3-one hydrochloride;6-(4-(Pyridin-4-ylamino)phenyl)-4,5
Cas No.	98326-33-1
分子式	C₁₅H₁₅ClN₄O
分子量	302.76
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	Senazodan (MCI 154) (hydrochloride) 是一种 Ca²⁺ 感光剂，同时可抑制 PDE III 的活性。
生物活性	Senazodan (MCI 154) (hydrochloride), as a Ca sensitiser, shows inhibition effect on PDE III.
性状	Solid
IC50 & Target[1][2]	PDE III
体外研究(In Vitro)	Senazodan (hydrochloride) seems to affect directly the actin-myosin crossbridge kinetics, and increases myosin ATPase activity. Senazodan (hydrochloride) produces a concentration-dependent increase in tension development. Senazodan (hydrochloride) enhances Ca binding to myofilaments and to purified cardiac troponin C. Senazodan (hydrochloride) also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III.Senazodan (0.1 nM~0.1 mM) (hydrochloride) shows that the contractile response of superior mesenteric arterie (SMA) to norepinephrine (NE) after hemorrhagic shock is significantly decreased as compared with the normal control group. Senazodan (0.01 mM) (hydrochloride) pretreatment prevents the effects of Ang II, and the concentration-response curve of Ca is shifted to the right as compared with Ang II-alone group.
体内研究(In Vivo)	Senazodan (0.1~2.0 mg/kg; left femoral vein catheterization infusion) (hydrochloride) decreases the pressor effect of norepinephrine (NE). Senazodan (0.1 mg/kg; i.v.) (hydrochloride) makes LVSP, IP, MC, and Lo all increased significantly, while heart rate is not obviously changed and left ventricular end-diastolic pressure (LVEDP) is reduced remarkably. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Lehtonen LA, et al. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43(3):187-203. [2]. Erhardt L. An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opin Investig Drugs. 2005 Jun;14(6):659-70. [3]. Yang G, et al. Effects of MCI-1

溶解度数据	In Vitro: DMSO : 50 mg/mL (165.15 mM; Need ultrasonic)H₂O : 25 mg/mL (82.57 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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