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NVP-ACC789

(Synonyms: ACC-789; ZK202650)

目录号: PL08990 纯度: ≥99%

NVP-ACC789 是人 VEGFR-1，VEGFR-2 (鼠 VEGFR-2)，VEGFR-3 和 PDGFR-β 的抑制剂，IC50 值分别为 0.38，0.02 (0.23)，0.18 和 1.4 μM。

CAS No. :300842-64-2

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PL08990-10mM*1mLinDMSO	10mM*1mLinDMSO	¥884.00	请登录
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中文名称	NVP-ACC789
中文别名	N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺;N-(3-溴-4-甲基苯基)-4-(吡啶-4-甲基)二氮杂萘-1-胺
英文名称	NVP-ACC789
英文别名	1-Phthalazinamine,N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-;ACC-789;N-(3-BROMO-4-METHYLPHENYL)-4-(4-PYRIDINYLMETHYL)-1-PHTHALAZINAMINE;N-(3-bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;NVP-ACC-789;ZK-202650;NVP-ACC789
Cas No.	300842-64-2
分子式	C₂₁H₁₇N₄Br
分子量	405.29
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	NVP-ACC789 是人 VEGFR-1，VEGFR-2 (鼠 VEGFR-2)，VEGFR-3 和 PDGFR-β 的抑制剂，IC50 值分别为 0.38，0.02 (0.23)，0.18 和 1.4 μM。

产品详情	NVP-ACC789 是人 VEGFR-1，VEGFR-2 (鼠 VEGFR-2)，VEGFR-3 和 PDGFR-β 的抑制剂，IC₅₀ 值分别为 0.38，0.02 (0.23)，0.18 和 1.4 μM。
生物活性	NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.
性状	Solid
IC50 & Target[1][2]	VEGFR-2 0.02 μM (IC50) VEGFR-1 0.38 μM (IC
体外研究(In Vitro)	The enzymatic kinase assays demonstrate that NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC50s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively. In VEGF-treated cultures, addition of the VEGFR-2 inhibitor NVP-ACC789 reduces BME cell number to baseline levels from 1 μM. Likewise, bFGF-induced BME cell proliferation is reduced markedly by NVP-ACC789 from 1 to 10 μM, without however reaching basal levels. NVP-ACC789 is found to be a potent inhibitor of VEGF-induced HUVE cell proliferation with an IC50 of 1.6 nM. NVP-ACC789 also completely inhibits VEGF-induced BME and BAE cell invasion and VEGF-C-induced BAE cell invasion. The inhibition is dose-dependent in both cell types with a maximal effect from 1 μM. has not independently confirmed the accuracy
体内研究(In Vivo)	NVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tille JC, et al. Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basicfibroblast growth factor-induced angiogenesis in vivo and in vitro. J Pharmacol Exp Ther. 2001 Dec;299(3):1073-85.

溶解度数据	In Vitro: DMSO : 25 mg/mL (61.68 mM; Need ultrasonic)配制储备液

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[1]. Tille JC, et al. Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basicfibroblast growth factor-induced angiogenesis in vivo and in vitro. J Pharmacol Exp Ther. 2001 Dec;299(3):1073-85.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

NVP-ACC789

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