T0467 以 PINK1 依赖的方式激活线粒体 parkin 易位。T0467 不诱导多巴胺能神经元中 PINK1 的线粒体聚集。T0467 是一种潜在的PINK1-Parkin 信号激活化合物，可用于帕金森病及相关疾病的研究。

T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinsons disease and related disorders research.

Solid

T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells.
T0467 does not show obvious toxicity in Drosophila at concentrations <50 μM. All cpds examined mitigated the PINK1 inactivation-mediated larval locomotion defects and mitochondrial morphological defects and reduced ATP production. T0467 and KTP improved the mitochondrial Ca response in  Drosophila  larval muscles.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Kahori Shiba-Fukushima, et al. A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. iScience. 2020 May 22;23(5):101048.

In Vitro: DMSO : 33.33 mg/mL (75.49 mM; Need ultrasonic)配制储备液