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Mitochondrial fusion promoter M1

目录号: PL07348 纯度: ≥99%

Mitochondrial fusion promoter M1 是线粒体动态调节剂。Mitochondrial fusion promoter M1 保持线粒体功能并促进细胞呼吸。Mitochondrial fusion promoter M1 减轻了心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。

CAS No. :219315-22-7

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PL07348-100mg	100mg	¥1975.00	请登录
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PL07348-10mM*1mLinDMSO	10mM*1mLinDMSO	¥884.00	请登录

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中文名称	Mitochondrial fusion promoter M1
中文别名	(E)-4-氯-2-(1-(2-(2,4,6-三氯苯基)肼)乙基)苯酚
英文名称	Mitochondrial fusion promoter M1
英文别名	Mitochondrial Fusion Promoter M1;4-chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl) phenol;Dtxsid70893486;(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol;1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
Cas No.	219315-22-7
分子式	C₁₄H₁₀Cl₄N₂O
分子量	364.05
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months
详情描述	Mitochondrial fusion promoter M1 是线粒体动态调节剂。Mitochondrial fusion promoter M1 保持线粒体功能并促进细胞呼吸。Mitochondrial fusion promoter M1 减轻了心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。

产品详情	Mitochondrial fusion promoter M1 是线粒体动态调节剂。Mitochondrial fusion promoter M1 保持线粒体功能并促进细胞呼吸。Mitochondrial fusion promoter M1 减轻了心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。
生物活性	Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury.
性状	Solid
体外研究(In Vitro)	Mitochondrial fusion promoter M1 (5-25 μM; 24 h) promotes mitochondrial elongation in both Mitofusin-1 and Mitofusin -2 knock-out fibroblasts. Mitochondrial fusion promoter M1 (20 μM; 12 h) decreases mito ROS to 1.0±0.44 fold, enhances mitochondrial membrane potential from 0.29±0.05 fold to 0.5±0.07 fold and restores mitochondrial architecture in BRIN-BD11 pancreatic beta cells. Mitochondrial fusion promoter M1 (20 μM; 12 h) prevents the impairment of oxygen consumption rate in pancreatic beta cells due to cholesterol exposure. Mitochondrial fusion promoter M1 (20 μM; 12 h) prevents the impairment of non-mitochondrial respiration and extracellular acidification rate (ECAR) in cholesterol enriched pancreatic beta cells. Mitochondrial fusion promoter M1 (20 μM; 12 h) restores Glucose Stimulated Insulin Secretion (GSIS) in cholesterol treated pancreatic beta cells
体内研究(In Vivo)	Mitochondrial fusion promoter M1 (2 mg/kg; i.v.) significantly protects rats with cardiac I/R injury against brain damage. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Surinkaew P, et, al. Mitochondrial Fusion Promoter Alleviates Brain Damage in Rats with Cardiac Ischemia/Reperfusion Injury. J Alzheimers Dis. 2020;77(3):993-1003. [2]. Wang D, et, al. A small molecule promotes mitochondrial fusion in mammalian cells. Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9302-5.

溶解度数据	In Vitro: DMSO : 50 mg/mL (137.34 mM; Need ultrasonic)配制储备液

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[1]. Surinkaew P, et, al. Mitochondrial Fusion Promoter Alleviates Brain Damage in Rats with Cardiac Ischemia/Reperfusion Injury. J Alzheimers Dis. 2020;77(3):993-1003.
[2]. Wang D, et, al. A small molecule promotes mitochondrial fusion in mammalian cells. Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9302-5.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Mitochondrial fusion promoter M1

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