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产品总数：60959
| 中文名称 |
MPP+-d3 (iodide)
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|---|---|
| 中文别名 |
N-甲基-d3-4-苯基吡啶ium io二de;N-甲基-D3-4-苯基碘吡啶;N-甲基-D3-4-苯基碘化吡啶;碘化N-甲基-D3-4-苯基吡啶正离子
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| 英文名称 |
MPP+-d3 (iodide)
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| 英文别名 |
1-(METHYL-D3)-4-PHENYLPYRIDINIUM IODIDE&;4-phenyl-1-(trideuteriomethyl)pyridin-1-ium,iodide;MPP-D3 IODIDE (1-METHYL-4-PHENYLPYRIDINIUM-D3 IODIDE);N-(Methyl-d3)-4-phen;N-(Methyl-d3)-4-phenylpyridinium Iodide;MPP+-d3 Iodide;N-Methyl-d3-4-phenylpyridinium iodide;MPP+-d3 (iodide)
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| Cas No. |
207556-07-8
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| 分子式 |
C12H9D3In
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| 分子量 |
300.15
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| 包装储存 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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| 产品详情 |
MPP+-d3 (iodide) 是 MPP+ (iodide) 氘代物。MPP+ iodide 是神经毒素 MPTP 的一种有毒代谢物，通过选择性破坏黑质多巴胺能神经元，在动物模型中引起帕金森病症状。MPP+ iodide 被多巴胺转运体吸收进入多巴胺能神经元，通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。MPP+ iodide 也是 5-羟色胺转运体 (SERT) 的高亲和力底物。
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| 生物活性 |
MPP+-d 3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinsons disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
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| 体外研究(In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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| 参考文献 |
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.[2]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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