Thalidomide-4-OH|5054-59-1|-陌孚医药/Medlife

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Thalidomide-4-OH

目录号: PL06622 纯度: ≥99%

CAS No. :5054-59-1

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中文名称	Thalidomide-4-OH
中文别名	2-(2,6-二氧代 - 哌啶-3-基)-4-羟基 - 异吲哚-1,3-二酮;萨力多胺杂质
英文名称	Thalidomide-4-OH
英文别名	2-(2,6-二氧代 - 哌啶-3-基)-4-羟基 - 异吲哚-1,3-二酮;E3 ligase Ligand 2;4-Hydroxy thalidomide;4-Hydroxythalidomide;2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione;4-Hydroxy thalidomide, (+/-)-;3-Hydroxythalidomide;Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-hydroxy-;XMPJICVFSDYOEG-UHFFFAOYSA-N;BCP20021;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-;SY233142;4-hydroxy-2-(2,6-;Thalidomide-4-OH;4-Hydroxy-thalidomide;Q27281110
Cas No.	5054-59-1
分子式	C₁₃H₁₀N₂O₅
分子量	274.23
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	Thalidomide-4-OH (Cereblon ligand 2) 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-4-OH (Cereblon ligand 2) 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。
生物活性	Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs.
性状	Solid
IC50 & Target[1][2]	Cereblon
体外研究(In Vitro)	Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. Thalidomide-OH is a putative hydroxylated thalidomide metabolite. Thalidomide-OH has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). Thalidomide-OH does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.

溶解度数据	In Vitro: DMSO : ≥ 36.5 mg/mL (133.10 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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