T-1105，T-705 的结构类似物，是一种广谱 病毒聚合酶 (polymerase) 抑制剂。T-1105 在转化为核糖核苷三磷酸 (RTP) 代谢物后抑制 RNA 病毒的聚合酶。T-1105 对各种 RNA 病毒表现出抗病毒活性，T-1105 可由烟酰胺单核苷酸腺苷酰转移酶形成。

T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase.

Solid

EC50: 17 μM (parainfluenza-3 virus); EC50: 24 μM (Punta Toro virus) .
EC50: 97.5 μM (ZIKV strain SZ01)

T-1105 has antiviral activity against various RNA viruses, including Zika virus (ZIKV), influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), and foot-and-mouth disease virus (FMDV).
T-1105 has good anti-RNA virus activity with values EC50 of 17 μM and 24 μM for parainfluenza-3 virus and Punta Toro virus in MDCK cells.
T-1105 is a potential inhibitor of Zika virus replication.
T-1105 can inhibit the SFTSV replication with an value IC50 of 49 μM in Vero cells and is not affect cell viability in 0-3 μM. has not independently confirmed the accuracy of these methods. They are for reference only.

T-1105 (Oral, 200 mg/kg, twice daily for 6 days) effectively inhibits the virus replication in the infected pigs. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Pigs

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Huchting J, et al. Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir). Antiviral Res. 2019 Jul;167:1-5.
[2]. Furuta Y, et al. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009 Jun;82(3):95-102.

In Vitro: DMSO : 25 mg/mL (179.71 mM; Need ultrasonic)配制储备液