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Triazavirin

目录号: PL04937 纯度: ≥99%

Triazavirin 是一种核酸的核苷类似物和一种抗病毒剂。Triazavirin 通过抑制病毒 RNA 和 DNA 的合成以及基因组片段的复制而起作用。Triazavirin 还是一种对流感传播阶段有效的保护剂。

CAS No. :928659-17-0

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中文名称	Triazavirin
中文别名	瑞米拉韦
英文名称	Triazavirin
英文别名	Triazavirin;G1JE34QF2S;TRIAZAVIRINE;Riamilovir sodium dihydrate;(1,2,4)Triazolo(5,1-C)(1,2,4)triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate
Cas No.	928659-17-0
分子式	C₅H₆N₆NaO₄S
分子量	269.19
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Triazavirin 是一种核酸的核苷类似物和一种抗病毒剂。Triazavirin 通过抑制病毒 RNA 和 DNA 的合成以及基因组片段的复制而起作用。Triazavirin 还是一种对流感传播阶段有效的保护剂。

产品详情

生物活性

Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza.

性状

Solid

IC50 & Target[1][2]

Nucleoside analogue; Influenza virus

体外研究(In Vitro)

The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin ) by accumulation in the SKEV cell culture. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Kozhikhova KV, et al. Preparation of chitosan-coated liposomes as a novel carrier system for the antiviral drug Triazavirin. Pharm Dev Technol. 2018 Apr;23(4):334-342.
[2]. Loginova SIa, et al. Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture. Antibiot Khimioter. 2014;59(1-2):3-5.

溶解度数据	In Vitro: DMSO : 125 mg/mL (436.76 mM; Need ultrasonic)H₂O : 50 mg/mL (174.70 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Triazavirin

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