GLP-2(3-33)|275801-62-2|-陌孚医药/Medlife

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GLP-2(3-33)

目录号: PL05975 纯度: ≥99%

CAS No. :275801-62-2

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中文名称	GLP-2(3-33)
中文别名	激动剂多肽GLP-2(3-33)
英文名称	GLP-2(3-33)
英文别名	GLP-2(3-33);L-Aspartic acid, L-α-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-alanyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleuc...;GLP-2 (3-33);glucagon-like peptide 2-(3-33);275801-62-2;GLXC-26361;L-Aspartic acid, L-α-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-alanyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-
Cas No.	275801-62-2
分子式	C₁₅₆H₂₄₂N₄₀O₅₃S
分子量	3557.89
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	GLP-2(3-33) 由二肽基肽酶 IV (DPPIV) 产生，是一种 GLP-2 受体部分激动剂 (EC₅₀=5.8 nM)。
生物活性	GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC 50 =5.8 nM).
性状	Solid
体外研究(In Vitro)	GLP-2 is secreted as a 33-amino acid peptide, but is rapidly degraded at an N-terminus site to GLP-2(3-33) in circulation, in large part, by dipeptidylpeptidase IV (DPPIV). GLP-2 (3-33) acts as a partial agonist with potential competitive antagonistic properties on the GLP-2 receptor. In the GLP-2 receptor-binding assay, the binding IC50 for GLP-2 1–33 was 3.1 nM, and it was 41 nM for GLP-2 3-33. Thus, GLP-2 3–33 had 7.5% binding affinity compared to GLP-2 1-33. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	GLP-2(3-33) (60 ng; once a day i.p. for 4 weeks) increases dyslipidemia and hepatic lipid accumulation in HFD-fed mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J (
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	DGSFSDEMNTILDNLAARDFINWLIQTKITD
参考文献	[1]. Thulesen J, Knudsen LB, Hartmann B, Hastrup S, Kissow H, Jeppesen PB, ?rskov C, Holst JJ, Poulsen SS. The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist. Regul Pept. 2002 Jan 15;103(1):9-15. [2]. Baldassano S, et al. Influence of endogenous glucagon-like peptide-2 on lipid disorders in mice fed a high-fat diet. Endocr Res. 2016 Nov;41(4):317-324.

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