Glucagon (1-29), bovine, human, porcine|16941-32-5|(胰高血糖素; Glucagon)-陌孚医药/Medlife

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Glucagon (1-29), bovine, human, porcine (Synonyms: 胰高血糖素; Glucagon)

目录号: PL05754 纯度: ≥99%

CAS No. :16941-32-5

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中文名称	Glucagon (1-29), bovine, human, porcine
中文别名	高血糖素;胰高血糖素;醋酸胰高血糖素;2-哌啶甲酸甲酯;盐酸高血糖素;盐酸胰高血糖素;盐酸胰高血糖素 Glucagon Acetate;盐酸胰高血糖素 GlucagonAcetate;重组人胰高血糖素;高血糖素(GLUCAGON);胰高血糖素(1-29),牛,人,猪;胰岛素肽;醋酸胰高血糖素 16941-32-5;胰高血糖素(Glu)
英文名称	Glucagon (1-29), bovine, human, porcine
英文别名	glucagon;Glucagon (1-29) (human, bovine, porcine);Glucagon, human recombinant;H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH;Glucagon (1-29) (human, rat, porcine);Glucagon Hydrochloride;Glucagon(1-29)(Human);Glucagon(1-29),bovine,human,porcine;Porcine glucagon;Gastrin Releasing Peptide, porcine;Glucagon 1-29;GLUCAGON 1-37;GLUCAGON 37;GLUCAGON ACETATE;Glucaton;OXYNTOMODULIN;OXYNTOMODULIN (PORCINE);Glucagon(pig);77: PN: WO0183527 SEQID: 77 claimedsequence;Bovine glucagon;Glucagon (Canis familiaris stomach);Glucagon(Mesocricetus auratus);Glucagon (Saimiri sciureus);Glucagon (Xenopus laevis);Glucagon (dog pancreas);Glucagon (dog);Glucagon (human);Glucagon (ox);Glukagon Novo;Human glucagon;159: PN: WO0069900 SEQID: 338 unclaimedsequence;18: PN: WO0039278 SEQID: 24 unclaimed sequence;1: PN: WO0053777 SEQID: 1 unclaimed protein;Glucagon HCl;Glucagon【dog】;Glucagon, USP;35: PN: WO2006017688 SEQID: 35 unclaimed sequence;393:PN: WO2007146038 SEQID: 393 unclaimed protein;3: PN: WO2006064378 SEQID: 3unclaimed sequence;474: PN: US20080312157 SEQID: 528 unclaimed sequence;6: PN:JP2003161732 SEQID: 6 unclaimed sequence;84: PN: US20080213898 SEQID: 82 claimed sequence;84: PN:WO2008041849 SEQID: 86 claimed protein;8: PN: WO2008048607 SEQID: 7 unclaimedsequence;10: PN: WO2008036970 FIGURE: 2 unclaimed sequence;11: PN: WO2004111078SEQID: 62 unclaimed sequence;11: PN: WO2008041849 SEQID: 11 claimed protein;121: PN: US20060293232 PAGE: 15 unclaimed sequence;148: PN: WO2008033395SEQID: 160 unclaimed sequence;15: PN: WO2008022716 SEQID: 18 unclaimed sequence;15: PN:WO2008101017 SEQID: 1 claimed protein;17: PN: WO2008086086 SEQID: 1 unclaimedprotein;1: PN: US20040002442SEQID: 1 unclaimed sequence;1:PN: WO2005019261 SEQID: 1 unclaimed sequence;1: PN: WO2007056362 SEQID: 1claimed protein;1: PN: WO2008062420 SEQID: 1 unclaimed sequence;1: PN:WO2009099763 SEQID: 1 unclaimed protein;1: PN: WO2009155258 SEQID: 1 claimedprotein;2149: PN: WO03060071 SEQID: 2211 unclaimed;24: PN: WO2010013012SEQID: 24 unclaimed sequence;272: PN: US20090175821 SEQID: 338 claimedprotein;2: PN: WO2008076933 SEQID: 8 claimed protein;31: PN: WO03071268 PAGE:28 unclaimed sequence;Glucagon （GLU）;Glucagon (1-29), bovine, human, porcine
Cas No.	16941-32-5
分子式	C₁₅₃H₂₂₅N₄₃O₄₉S
分子量	3482.75
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	Glucagon (1-29), bovine, human, porcine 是由胰腺 α 细胞产生的一种多肽激素。Glucagon 促进糖异生。Glucagon (1-29), bovine, human, porcine 可激活 HNF4α 并促进 HNF4α 磷酸化。
生物活性	Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation.
性状	Solid
体外研究(In Vitro)	Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes. Glucagon (100 nM) increases phosphorylayion of HNF4α. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Sequence	His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
参考文献	[1]. Song WJ, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1;19(4):667-81. [2]. Hirota K, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003 Apr 11;278(15):13056-60.

溶解度数据	In Vitro: H₂O : 6.67 mg/mL (1.92 mM; ultrasonic and adjust pH to 3 with HCl)DMSO : 2.5 mg/mL (0.72 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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