PD 404182 是一种有效的、竞争性的人类二甲基精氨酸二甲基氨基水解酶 1 (DDAH1) 抑制剂，IC₅₀ 值为 9 μM。PD 404182 在体外表现出抗血管生成和抗病毒活性。

PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC 50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.

Solid

IC50: 9 μM (DDAH1)

PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.
PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.
PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM.
PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Ghebremariam YT, et, al. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan; 348(1): 69-76.
[2]. Chamoun-Emanuelli AM, et, al. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014; 58(2): 687-97.

In Vitro: DMSO : 50 mg/mL (230.11 mM; Need ultrasonic)配制储备液