Bleomycin hydrochloride 是一种 DNA 损伤剂，抑制 DNA 合成。Bleomycin hydrochloride 是一种抗肿瘤抗生素 (antibiotic)。

Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic.

Solid

Bleomycin hydrochloride is chosen as the best-studied micronucleus inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation.
The IC50 value of Bleomycin hydrochloride for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin; IC50 values are 14.2±2.8 nM and 13.0±1.1 nM, respectively.
Bleomycin hydrochloride (50, 100?μM; for 24, 48?h) induce pulmonary fibrosis in RLE-6TN cell (50?μM) and A549 cell (100?μM).
has not independently confirmed the accuracy of these methods.

Bleomycin hydrochloride treatment (3.5-4.0?mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study.
Bleomycin hydrochloride (3.5-4.0?mg/kg; intra-tracheal) produces a statistically significant increase in lung hydroxyproline levels, and also increases right caudal lung lobe mass.
Bleomycin hydrochloride (intratracheal instillation; 5.0?mg/kg/day) induces pulmonary fibrosis in eighty 8-week-old male BALB/c mice with weight about 20-30?g. Bleomycin induces the expression levels of α-SMA and collagen I.
Bleomycin hydrochloride (intratracheally; 2.5?mg/kg; 1.25?mg/ml, approximately 50?μl per mouse) induces pulmonary fibrosis in male C57BL/6 mice (8?weeks old, average weight approximately 24.5?g).

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

[1]. Hovhannisyan G, et al. Comparative analysis of individual chromosome involvement in micronuclei induced by bleomycin in human leukocytes. Mol Cytogenet. 2016 Jun 21;9:49.
[2]. Jaaskela-Saari HA, et al. Squamous cell cancer cell lines: sensitivity to bleomycin and suitability for animal xenograft studies. Acta Otolaryngol Suppl. 1997;529:241-4.

In Vitro: H₂O : 100 mg/mL (Need ultrasonic)DMSO : 50 mg/mL (ultrasonic and warming and heat to 60°C)In Vivo: