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S-23

目录号: PL02023 纯度: ≥99%

S-23 是一种口服选择性雄激素受体调节剂 (SARM)，Ki 为 1.7 nM。S-23 诱导 CV-1 细胞雄激素受体介导的转录激活。S-23 增加去势大鼠前列腺、精囊和肛提肌重量。

CAS No. :1010396-29-8

商品编号	规格	价格	会员价
PL02023-5mg	5mg	¥393.00	请登录
PL02023-10mg	10mg	¥658.00	请登录
PL02023-25mg	25mg	¥1325.00	请登录
PL02023-50mg	50mg	¥1975.00	请登录
PL02023-100mg	100mg	¥6268.00	请登录
PL02023-200mg	200mg	询价	询价
PL02023-500mg	500mg	询价	询价
PL02023-1 mL x 10 mM (in DMSO)	1 mL x 10 mM (in DMSO)	¥443.00	请登录

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中文名称	S-23
英文名称	S-23
英文别名	(S)-3-(4-Chloro-3-fluorophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide;S 23;S-23;(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;(2S)-3-(4-Chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;S 23 (contraceptive);S-23 99% White powder
Cas No.	1010396-29-8
分子式	C₁₈H₁₃ClF₄N₂O₃
分子量	416.80
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	S-23 是一种口服选择性雄激素受体调节剂 (SARM)，Ki 为 1.7 nM。S-23 诱导 CV-1 细胞雄激素受体介导的转录激活。S-23 增加去势大鼠前列腺、精囊和肛提肌重量。

产品详情	S-23 是一种口服选择性雄激素受体调节剂 (SARM)，K_i 为 1.7 nM。S-23 诱导 CV-1 细胞雄激素受体介导的转录激活。S-23 增加去势大鼠前列腺、精囊和肛提肌重量。
生物活性	S-23 is an orally active selective androgen receptor modulator (SARM) with a K i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
性状	Solid
IC50 & Target[1][2]	Ki: 1.7 nM (Androgen receptor)
体外研究(In Vitro)	S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED 50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively. has not independently confirmed the accuracy of these methods. They are for reference only. Animal
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):38 [2]. Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2(11-12):589-598.

溶解度数据	In Vitro: DMSO : 100 mg/mL (239.95 mM; Need ultrasonic)配制储备液

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[1]. Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):38
[2]. Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2(11-12):589-598.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

S-23

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