ACP-105|899821-23-9|-陌孚医药/Medlife

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ACP-105

目录号: PL02022 纯度: ≥99%

CAS No. :899821-23-9

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中文名称	ACP-105
英文名称	ACP-105
英文别名	ACP105;ACP-105;2-Chloro-4-[(1R,5R)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl]-3-methylbenzonitrile;BDBM50415086;2-Chloro-4-[(1R,5S)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl]-3-methylbenzonitrile;AMY32474;ZKB82123;2-Chloro-4-[(1alpha,5alpha)-3alpha-hydroxy-3-methyl-8-azabicyclo[3.2.1]octane-8-yl]-3-methylbenzonitrile;2-Chloro-4-[(3-endo)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]oct-8-yl]-3-methylbenzonitrile (ACI);ACP 105
Cas No.	899821-23-9
分子式	C₁₆H₁₉ClN₂O
分子量	290.79
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	ACP-105 是一种可口服的、有选择性的、有效的雄激素受体调节剂 (SARM), 其对野生型 AR 和 T877A 突变型 AR 的 pEC₅₀ 值分别为 9.0 和 9.3。
生物活性	ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC 50 s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.
性状	Solid
IC50 & Target[1][2]	pEC50: 9.0 (AR wild type), 9.3 (AR T877A mutant).
体外研究(In Vitro)	ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 (compound 1) in human hepatocytes is measured and found to be 5.0 h. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	ACP-105 enhances freezing in both sham-irradiated and irradiated mice (effect of ACP-105: F=5.44; p=0.028). For MAP-2 immunoreactivity in the cortex of sham-irradiated mice, there is a brain area×ACP-105 interaction (F=6.655; p=0.0027). While ACP-105 reduces MAP-2 immunoreactivity in the sensorymotor cortex, there is a trend towards increased MAP-2 immunoreactivity in the enthorhinal cortex. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Schlienger N, et al. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. J Med Chem. 2009 Nov 26;52(22):7186-91. [2]. Dayger C, et al. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. Brain Res. 2011 Mar 24;1381:134-40.

溶解度数据	In Vitro: DMSO : ≥ 103 mg/mL (354.21 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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