Bifluranol (BX341) 具有抗雄激素活性。

Bifluranol (BX341) is an anti-androgen.

Solid

Androgen Receptor

The absorption, distribution and excretion of Bifluranol have been studied in mouse, rat, ferret and dog; Bifluranol is readily absorbed following oral administration, but blood concentrations of Bifluranol are low due to hepatic uptake and biliary excretion. After intravenous administration of [H]Bifluranol to rats (200 μg/kg) and ferrets (60 μg/kg) the blood concentrations of H decreases rapidly for the first 2 to 3 h, with the decrease being more rapid in females ( 18 min for rat, 30 min for ferret) than males (1.0 h for rat, 1.4 h for ferret). This is followed by a much slower decline (40 h for rat, 20 h for ferret) to concentrations at 96 h of less than 15 ng Bifluranol equivalents mL (rat) or 1 ng Bifluranol equivalents mL (ferret). has not independently confirmed the accuracy of these methods. They are for refere

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Pope DJ, et al. Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species. J Pharm Pharmacol. 1981 May;33(5):297-301.

In Vitro: DMSO : 100 mg/mL (342.09 mM; Need ultrasonic)配制储备液