BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke.
性状
Solid
体外研究(In Vitro)
BMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay
Cell Line:
IGR39 and Panc-1 cells
Concentration:
20 or 40 μM
Incubation Time:
Result:
Activated BK channels in less than 50% IGR39 cells and led to less than two-fold potentiation in Panc-1 cells.
Promoted the activation of a voltage-independent K conductance at negative voltages.
体内研究(In Vivo)
BMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 μg/kg, intravenously (i.v.))
Dosage:
10-100 μg/kg
Administration:
Intravenous injection; 10-100 μg/kg; once
Result:
Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.