Odanacatib|603139-19-1|(奥当卡替; MK-0822)-陌孚医药/Medlife

您当前的位置：

Odanacatib (Synonyms: 奥当卡替; MK-0822)

目录号: PL15167 纯度: ≥99%

CAS No. :603139-19-1

商品编号	规格	价格	会员价
PL15167-2mg	2mg	¥1526.00	请登录
PL15167-5mg	5mg	¥2443.00	请登录
PL15167-10mg	10mg	¥4259.00	请登录
PL15167-50mg	50mg	¥12697.00	请登录
PL15167-100mg	100mg	¥19287.00	请登录
PL15167-200mg	200mg	询价	询价
PL15167-500mg	500mg	询价	询价
PL15167-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2823.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Odanacatib
中文别名	(2S)-N-(1-氰基环丙基)-4-氟-4-甲基-2-[[(1S)-2,2,2-三氟-1-[4'-(甲基磺酰基)[1,1'-联苯]-4-基]乙基]氨基]戊酰胺;Odanacatib (MK-0822) 抑制剂;奥当卡替;奥当卡替 MK-0822;奥当卡替(MK-0822);硫利达嗪盐酸盐
英文名称	Odanacatib
英文别名	Odanacatib;(2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]pentanamide;Odanacatib (MK-0822);(2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide;MK0822;MK-0822;UNII-N673F6W2VH;MK 0822;Odanacatib (MK 0822);N673F6W2VH;(S)-N-(1-CYANOCYCLOPROPYL)-4-FLUORO-4-METHYL-2-((S)-2,2,2-TRIFLUORO-1-(4'-(METHYLSULFONYL)BIPHENYL-4-YL)ETHYLAMINO)PENTANAMIDE;(2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]
Cas No.	603139-19-1
分子式	C₂₅H₂₇F₄N₃O₃S
分子量	525.56
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Odanacatib (MK-0822) 是有效，选择性的组织蛋白酶K抑制剂，IC₅₀ 分别为0.2 nM 和 1 nM。

生物活性

Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC 50 of 0.2 nM for human cathepsin K.

性状

Solid

IC50 & Target[1][2]

IC50: 0.2 nM (Human Cathepsin K), 1 nM (Rabbit Cathepsin K)

体外研究(In Vitro)

Odanacatib is a weak inhibitor of antigen presentation, measured in a mouse B cell line (IC50=1.5±0.4 μM), compared to the Cat S inhibitor LHVS (IC50=0.001 μM) in the same assay. Odanacatib also shows weak inhibition of the processing of the MHC II invariant chain protein Iip10 in mouse splenocytes compared to LHVS (minimum inhibitory concentration 1-10 μM versus 0.01 μM, respectively). Odanacatib reduces resorption activity as measured by CTx release (IC50=9.4 nM) or resorption area (IC50=6.5 nM), but has no impact on OC activation. Odanacatib dose-dependently reduces CTx release with an IC50=9.4±1.0 nM. Odanacatib treated OC accumulates labeled degraded bone matrix proteins in CatK containing vesicles. has not independently confirmed the accuracy of these methods.

体内研究(In Vivo)

Odanacatib (30 mg/kg, orally, once daily) persistently suppresses bone resorption markers and serum bone formation markers versus vehicle-treated OVX monkeys. Odanacatib displays compartment-specific effects on trabecular versus cortical bone formation, with treatment resulting in marked increases in periosteal bone formation and cortical thickness in ovariectomized monkeys whereas trabecular bone formation is reduced. The bone volume/total volume (BV/TV) and bone mineral density (BMD) of the OVX?+?ODN-h group is significantly higher than that of the OVX?+?Veh group (p?<?0.05). The expressions of Runx2, Collagen-1, BSP, Osterix, OPN and SPP1 are significantly lower in the OVX?+?ODN-h group than in the OVX?+?Veh group (p?<?0.01). Compared with the OVX?+?Veh group, the expressions of Collagen-I, BSP, Osterix, OPN and ALP reduce in the OVX?+?ODN-l group, but are upregulated

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Jacques Yves Gauthier, et al. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8.
[2]. Leung P, et al. The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking. Bone. 2011 Oct;49(4):623-635.

溶解度数据	In Vitro: DMSO : ≥ 25 mg/mL (47.57 mM)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation