Z-WEHD-FMK|210345-00-9|(Z-WE(OMe)HD(OMe)-FMK)-陌孚医药/Medlife

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Z-WEHD-FMK (Synonyms: Z-WE(OMe)HD(OMe)-FMK)

目录号: PL13795 纯度: ≥98.0%

CAS No. :210345-00-9

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中文名称	Z-WEHD-FMK
中文别名	N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯
英文名称	Z-WEHD-FMK
英文别名	L-Histidinamide,N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-a-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-,methyl ester (9CI);L-Histidinamide,N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-a-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-;methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-ox;Z-WEHD-FMK;CASPASE-1 INHIBITOR TFA SALT;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA;Z-WEHD-FMK-TFA
Cas No.	210345-00-9
分子式	C₃₇H₄₂N₇O₁₀F
分子量	763.77
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Z-WEHD-FMK 是一种强效具有细胞通透性可逆的 caspase-1/5 抑制剂。Z-WEHD-FMK 也抑制 cathepsin B 的活性 (IC₅₀=6 μM)。Z-WEHD-FMK 可用于检测细胞凋亡。
生物活性	Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC 50 =6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.
性状	Solid
IC50 & Target[1][2]	Cathepsin B Caspase-1
体外研究(In Vitro)	Z-WEHD-FMK (80 μM; 9 hours) elicits a near-complete blockage of C. trachomatis -induced cleavage of golgin-84 and increases GM130 expression in cells. Z-WEHD-FMK (30?min before being exposed to E. piscicida ) effectively inhibits 0909I E. piscicida induced ZF4 cells cytotoxicity and pyroptotic morphology. And in addition, it also inhibits the cytotoxicity induced by cytosolic LPS delivery. Z-WEHD-FMK (20 μM;18-24 hours following Cr,Ni, and Co) significantly induces a decrease of 76% to 86% in IL-1β release with 200 to 400 ppm Cr, it also induces a decrease of 35% to 45% with 48 ppm Ni or higher, Finally, this caspase-1 inhibitor induced a decrease with 6 ppm Co, down to a level below the detection threshold, and a decrease of 40% to 48% with 12 to 24 ppm Co in bone marrow-derived macrophages (BMDM).
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
参考文献	[1]. Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4(6):473-8. [2]. Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052.

溶解度数据	In Vitro: DMSO : 100 mg/mL (130.93 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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