GSK591
目录号: PL15059 纯度: ≥99%
CAS No. :1616391-87-7
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PL15059-5mg 5mg ¥2092.50 请登录
PL15059-10mg 10mg ¥3802.50 请登录
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PL15059-50mg 50mg ¥9965.00 请登录
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中文名称
GSK591
英文名称
GSK591
英文别名
2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide.;EPZ015866;GSK 591;GSK3203591;GSK591;2-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carboxamide;2-(Cyclobutylamino)-N-[(2s)-3-(3,4-Dihydroisoquinolin-2(1h)-Yl)-2-Hydroxypropyl]pyridine-4-Carboxamide;GTPL8954;BDBM178085;s8111;EPZ015866(GSK591);SB19131;GSK591, >=97% (HPLC);A14374;US9675614, 188;G;2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxami
Cas No.
1616391-87-7
分子式
C22H28N4O2
分子量
380.48
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
GSK591 (EPZ015866) 是一种有效的,选择性的 protein methyltransferase 5 (PRMT5) 抑制剂,其 IC50 值为 4 nM。
生物活性
GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC 50 of 4 nM.
性状
Solid
IC50 & Target[1][2]
IC50: 4 nM (PRMT5)
体外研究(In Vitro)
GSK591 (5 μM; MCF7, T47D, and MCF10A cells) treatment suppresses breast cancer stem cells (BCSCs) proliferation and self-renewal. GSK591 reduces BCSCs numbers in vitro. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. [1] Kenneth W. Duncan et al. Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med. Chem. Lett., 2016, 7 (2), pp 162-166.
[2]. Chiang K, et al. PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. Cell Rep. 2017 Dec 19;21(12):3498-3513.
溶解度数据
In Vitro: DMSO : 50 mg/mL (131.41 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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